(2R)-2,3-dimethyl-2,5-dihydrofuran-2-carboxylic acid 2',6'-dimethyl-phenyl ester

Base Information

Chemical Name:(2R)-2,3-dimethyl-2,5-dihydrofuran-2-carboxylic acid 2',6'-dimethyl-phenyl ester
CAS No.:462118-89-4
Molecular Formula:C₁₅H₁₈O₃
Molecular Weight:246.306
Hs Code.:

Synonyms:(2R)-2,3-dimethyl-2,5-dihydrofuran-2-carboxylic acid 2',6'-dimethyl-phenyl ester

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Chemical Property of (2R)-2,3-dimethyl-2,5-dihydrofuran-2-carboxylic acid 2',6'-dimethyl-phenyl ester

Chemical Property:

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Technology Process of (2R)-2,3-dimethyl-2,5-dihydrofuran-2-carboxylic acid 2',6'-dimethyl-phenyl ester

There total 6 articles about (2R)-2,3-dimethyl-2,5-dihydrofuran-2-carboxylic acid 2',6'-dimethyl-phenyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 75.0%

: 576-26-1,25134-01-4
2.6-dimethylphenol

: 328575-53-7
(2R)-2,3-Dimethyl-2,5-dihydrofuran-2-carboxylic acid

: 462118-89-4
(2R)-2,3-dimethyl-2,5-dihydrofuran-2-carboxylic acid 2',6'-dimethyl-phenyl ester

Guidance literature:: With dmap; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In dichloromethane; at 20 ℃; for 16h;
DOI:10.1021/ol0263595

Reference yield:

: 22601-06-5
3-methylfuran-2-carbonyl chloride

: 462118-89-4
(2R)-2,3-dimethyl-2,5-dihydrofuran-2-carboxylic acid 2',6'-dimethyl-phenyl ester

Guidance literature:: Multi-step reaction with 5 steps

1.1: NaOH / CH₂Cl₂

2.1: NaH; TBAI / tetrahydrofuran

3.1: Li; NH₃ / tetrahydrofuran / -78 °C

3.2: 79 percent / isoprene / tetrahydrofuran

4.1: 85 percent / aq. hydrochloric acid / 2 h / Heating

5.1: 75 percent / EDCl; DMAP / CH₂Cl₂ / 16 h / 20 °C

With hydrogenchloride; dmap; sodium hydroxide; ammonia; tetra-(n-butyl)ammonium iodide; lithium; sodium hydride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; dichloromethane; 3.1: Birch reduction;
DOI:10.1021/ol0263595

Reference yield:

: 4412-96-8
3-methylfuran-2-carboxylic acid

: 462118-89-4
(2R)-2,3-dimethyl-2,5-dihydrofuran-2-carboxylic acid 2',6'-dimethyl-phenyl ester

Guidance literature:: Multi-step reaction with 6 steps

1.1: SOCl₂

2.1: NaOH / CH₂Cl₂

3.1: NaH; TBAI / tetrahydrofuran

4.1: Li; NH₃ / tetrahydrofuran / -78 °C

4.2: 79 percent / isoprene / tetrahydrofuran

5.1: 85 percent / aq. hydrochloric acid / 2 h / Heating

6.1: 75 percent / EDCl; DMAP / CH₂Cl₂ / 16 h / 20 °C

With hydrogenchloride; dmap; sodium hydroxide; thionyl chloride; ammonia; tetra-(n-butyl)ammonium iodide; lithium; sodium hydride; 1-ethyl-(3-(3-dimethylamino)propyl)-carbodiimide hydrochloride; In tetrahydrofuran; dichloromethane; 4.1: Birch reduction;
DOI:10.1021/ol0263595