2,2,2-Trichloro-acetimidic acid (4S,5S,6R)-5-iodo-4-phenyl-2-trichloromethyl-5,6-dihydro-4H-[1,3]oxazin-6-ylmethyl ester

Base Information

Chemical Name:2,2,2-Trichloro-acetimidic acid (4S,5S,6R)-5-iodo-4-phenyl-2-trichloromethyl-5,6-dihydro-4H-[1,3]oxazin-6-ylmethyl ester
CAS No.:229648-89-9
Molecular Formula:C₁₄H₁₁Cl₆IN₂O₂
Molecular Weight:578.876
Hs Code.:

Synonyms:2,2,2-Trichloro-acetimidic acid (4S,5S,6R)-5-iodo-4-phenyl-2-trichloromethyl-5,6-dihydro-4H-[1,3]oxazin-6-ylmethyl ester

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Chemical Property of 2,2,2-Trichloro-acetimidic acid (4S,5S,6R)-5-iodo-4-phenyl-2-trichloromethyl-5,6-dihydro-4H-[1,3]oxazin-6-ylmethyl ester

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Technology Process of 2,2,2-Trichloro-acetimidic acid (4S,5S,6R)-5-iodo-4-phenyl-2-trichloromethyl-5,6-dihydro-4H-[1,3]oxazin-6-ylmethyl ester

There total 1 articles about 2,2,2-Trichloro-acetimidic acid (4S,5S,6R)-5-iodo-4-phenyl-2-trichloromethyl-5,6-dihydro-4H-[1,3]oxazin-6-ylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 545-06-2
trichloroacetonitrile

: 229648-88-8
(2S,3E)-4-phenylbut-3-ene-1,2-diol

: 229648-89-9
2,2,2-Trichloro-acetimidic acid (4S,5S,6R)-5-iodo-4-phenyl-2-trichloromethyl-5,6-dihydro-4H-[1,3]oxazin-6-ylmethyl ester

Guidance literature:: With iodine(I) bromide; potassium carbonate; 1,8-diazabicyclo[5.4.0]undec-7-ene; Yield given; Multistep reaction; 1.) CH₃CN, -30 deg C, 2.) CH₃CN, -30 to -10 deg C;
DOI:10.1016/S0040-4039(99)00577-8

Reference yield:

: 229648-89-9
2,2,2-Trichloro-acetimidic acid (4S,5S,6R)-5-iodo-4-phenyl-2-trichloromethyl-5,6-dihydro-4H-[1,3]oxazin-6-ylmethyl ester

: 32981-85-4
methyl (2R,3S)-3-benzoylamino-2-hydroxy-3-phenylpropanoate

Guidance literature:: Multi-step reaction with 6 steps

1: 6N HCl / methanol / Ambient temperature

2: NaHCO₃ / methanol / 0 °C

3: 1.) NaIO₄, 2.) NaClO₂, NaH₂PO₄ / 1.) acetone, H₂O, RT, 2.) 2-methyl-2-butene, t-BuOH, H₂O, RT

4: methanol / 0 °C

5: H₂O, AcCl / methanol / Heating

6: NaHCO₃ / H₂O / Ambient temperature

With hydrogenchloride; sodium chlorite; sodium periodate; sodium dihydrogenphosphate; water; sodium hydrogencarbonate; acetyl chloride; In methanol; water;
DOI:10.1016/S0040-4039(99)00577-8

Reference yield:

: 229648-89-9
2,2,2-Trichloro-acetimidic acid (4S,5S,6R)-5-iodo-4-phenyl-2-trichloromethyl-5,6-dihydro-4H-[1,3]oxazin-6-ylmethyl ester

: 158722-22-6
(4S,5R)-2,4-diphenyl-4,5-dihydrooxazole-5-carboxylic acid

Guidance literature:: Multi-step reaction with 3 steps

1: 6N HCl / methanol / Ambient temperature

2: NaHCO₃ / methanol / 0 °C

3: 1.) NaIO₄, 2.) NaClO₂, NaH₂PO₄ / 1.) acetone, H₂O, RT, 2.) 2-methyl-2-butene, t-BuOH, H₂O, RT

With hydrogenchloride; sodium chlorite; sodium periodate; sodium dihydrogenphosphate; sodium hydrogencarbonate; In methanol;
DOI:10.1016/S0040-4039(99)00577-8