Technology Process of (2E,4S,5R)-4-benzyloxy-5-hydroxy-1-(1-methoxy-1-methylethyl)-2,4-dimethyl-2-heptene
There total 1 articles about (2E,4S,5R)-4-benzyloxy-5-hydroxy-1-(1-methoxy-1-methylethyl)-2,4-dimethyl-2-heptene which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
camphor-10-sulfonic acid;
In
benzene;
for 0.166667h;
Ambient temperature;
DOI:10.1248/cpb.37.1155
- Guidance literature:
-
Multi-step reaction with 4 steps
1: 1.) NaH, 2.) 10percent HCl / 1.) DMF, RT, 24 h, 2.) H2O, CH2Cl2, RT, 30 min
2: 99 percent / m-CPBA / CH2Cl2 / -20 deg C, 7 h, 0 deg C, 3 h
3: 91 percent / 1.0M B2H6, HMPA / tetrahydrofuran / -20 deg C, 10 h, RT
4: 97 percent / H2 / Raney Ni W-2 / ethanol / 7 h
With
hydrogenchloride; N,N,N,N,N,N-hexamethylphosphoric triamide; hydrogen; sodium hydride; 3-chloro-benzenecarboperoxoic acid; diborane;
Raney Ni W-2;
In
tetrahydrofuran; ethanol; dichloromethane;
DOI:10.1248/cpb.37.1155
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 1.) NaH, 2.) 10percent HCl / 1.) DMF, RT, 24 h, 2.) H2O, CH2Cl2, RT, 30 min
2: 99 percent / m-CPBA / CH2Cl2 / -20 deg C, 7 h, 0 deg C, 3 h
3: 91 percent / 1.0M B2H6, HMPA / tetrahydrofuran / -20 deg C, 10 h, RT
With
hydrogenchloride; N,N,N,N,N,N-hexamethylphosphoric triamide; sodium hydride; 3-chloro-benzenecarboperoxoic acid; diborane;
In
tetrahydrofuran; dichloromethane;
DOI:10.1248/cpb.37.1155
