ethyl (2S)-2-(oxan-2-yloxy)propanoate

Base Information

• Chemical Name: ethyl (2S)-2-(oxan-2-yloxy)propanoate
• CAS No.: 73208-70-5
• Molecular Formula: C10H18 O4
• Molecular Weight: 202.251
• DSSTox Substance ID: DTXSID60439236
• Nikkaji Number: J2.058.331B
• Mol file: 73208-70-5.mol

Synonyms:73208-70-5;ethyl (2S)-2-(oxan-2-yloxy)propanoate;Propanoic acid,2-[(tetrahydro-2H-pyran-2-yl)oxy]-, ethyl ester, (2S)-;(S)-2-(Tetrahydro-pyran-2-yloxy)-propionic acid ethyl ester;SCHEMBL9044976;DTXSID60439236;KXSNMSYBVPOHGJ-IENPIDJESA-N;AG-G-89175;A1-00704;ethyl (s)-2-[(tetrahydro-2h-pyran-2-yl)oxy]-propanoate;(S)-2-(Tetrahydro-2H-pyran-2-yloxy)propanoic acid ethyl ester;ethyl(2S)-2-(3,4,5,6-tetrahydro-2H-pyran-2-yloxy)propionate;Propanoic acid,2-[(tetrahydro-2H-pyran-2-yl)oxy]-,ethyl ester,(2S)-

Chemical Property of ethyl (2S)-2-(oxan-2-yloxy)propanoate

Chemical Property:

• PSA: 44.76000
• LogP: 1.48120
• XLogP3: 1.6
• Hydrogen Bond Donor Count: 0
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 5
• Exact Mass: 202.12050905
• Heavy Atom Count: 14
• Complexity: 181

Purity/Quality:

99% ^*data from raw suppliers

Ethyl-(2S)-2-(Oxan-2-yloxy)propanoate 95% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CCOC(=O)C(C)OC1CCCCO1
• Isomeric SMILES: CCOC(=O)[C@H](C)OC1CCCCO1

Technology Process of ethyl (2S)-2-(oxan-2-yloxy)propanoate

There total 2 articles about ethyl (2S)-2-(oxan-2-yloxy)propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

3,4-dihydro-2H-pyran (110-87-2) + (S)-Ethyl lactate (687-47-8) → ethyl (2S)-2-(tetrahydropyran-2-yloxy)propionate (73208-70-5)

Guidance literature:

With camphor-10-sulfonic acid; In diethyl ether; ice bath, 5 min; rt;

DOI:10.1021/ja00329a048

Reference yield: 95.0%

3,4-dihydro-2H-pyran (110-87-2) + (S)-Ethyl lactate (687-47-8) → Ethyl (S)-(-)-2-tetrahydropyran-2-yloxypropionate (3539-40-0,73208-70-5,83780-59-0,92077-90-2,92077-91-3)

Guidance literature:

With pyridinium p-toluenesulfonate; In dichloromethane; 1) 0 deg C, 3 h, 2) room temperature, 20 h;

DOI:10.1021/jo00046a020

Reference yield: 100.0%

ethyl (2S)-2-(tetrahydropyran-2-yloxy)propionate (73208-70-5) → (2S)-2-(tetrahydro-2H-pyran-2-yloxy)propan-1-ol (76946-21-9)

Guidance literature:

With lithium aluminium tetrahydride; In diethyl ether; 0 deg C, 165 min; reflux 2 h;

DOI:10.1021/ja00329a048

upstream raw materials:

3,4-dihydro-2H-pyran

(S)-Ethyl lactate

Downstream raw materials:

(S)-(+)-2-Tetrahydropyran-2-yloxypropan-1-ol

(2S)-2-(tetrahydro-2H-pyran-2-yloxy)propan-1-ol

(S)-(-)-2-(tetrahydropyranyloxy)propanol

(S)-(-)-2-(tetrahydropyranyloxy)propyl p-toluenesulfonate