(2S)-2-((Tetrahydro-2H-pyran-2-yl)oxy)propan-1-ol

Base Information

• Chemical Name: (2S)-2-((Tetrahydro-2H-pyran-2-yl)oxy)propan-1-ol
• CAS No.: 76946-21-9
• Molecular Formula: C8H16 O3
• Molecular Weight: 160.213
• Hs Code.: 2932999099
• DSSTox Substance ID: DTXSID20439171
• Nikkaji Number: J1.566.650A
• Mol file: 76946-21-9.mol

Synonyms:(2S)-2-((Tetrahydro-2H-pyran-2-yl)oxy)propan-1-ol;76946-21-9;(2S)-2-(oxan-2-yloxy)propan-1-ol;(S)-2-(TETRAHYDRO-PYRAN-2-YLOXY)-PROPAN-1-OL;(2S)-2-(Tetrahydro-2H-pyran-2-yloxy)-1-propanol;SCHEMBL2380317;DTXSID20439171;MKWQCXIXWYWZBA-JAMMHHFISA-N;AKOS006287681;(S)-1-hydroxy-2-tetrahydropyranyloxypropane;CS-0343042

Chemical Property of (2S)-2-((Tetrahydro-2H-pyran-2-yl)oxy)propan-1-ol

Chemical Property:

• Refractive Index: 1.4542
• Boiling Point: 263℃
• Flash Point: 113℃
• PSA: 38.69000
• Density: 1.04
• LogP: 0.91040
• Storage Temp.: 2-8°C
• XLogP3: 0.7
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 3
• Rotatable Bond Count: 3
• Exact Mass: 160.109944368
• Heavy Atom Count: 11
• Complexity: 106

Purity/Quality:

99% ^*data from raw suppliers

(2S)-2-((Tetrahydro-2H-pyran-2-yl)oxy)propan-1-ol 95+% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(CO)OC1CCCCO1
• Isomeric SMILES: C[C@@H](CO)OC1CCCCO1

Technology Process of (2S)-2-((Tetrahydro-2H-pyran-2-yl)oxy)propan-1-ol

There total 14 articles about (2S)-2-((Tetrahydro-2H-pyran-2-yl)oxy)propan-1-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 100.0%

ethyl (2S)-2-(tetrahydropyran-2-yloxy)propionate (73208-70-5) → (2S)-2-(tetrahydro-2H-pyran-2-yloxy)propan-1-ol (76946-21-9)

Guidance literature:

With lithium aluminium tetrahydride; In diethyl ether; 0 deg C, 165 min; reflux 2 h;

DOI:10.1021/ja00329a048

Reference yield: 92.0%

Ethyl (S)-(-)-2-tetrahydropyran-2-yloxypropionate (3539-40-0,73208-70-5,83780-59-0,92077-90-2,92077-91-3) → (S)-(-)-2-(tetrahydropyranyloxy)propanol (3539-39-7,76946-21-9,83780-60-3,92077-92-4,92077-93-5,124508-75-4,124508-76-5)

Guidance literature:

With lithium aluminium tetrahydride; In diethyl ether; 1) 0 deg C, 1 h, 2) room temperature, 1 h, 3) reflux, 20 h;

DOI:10.1021/jo00046a020

Reference yield: 88.5%

Ethyl (S)-(-)-2-tetrahydropyran-2-yloxypropionate (3539-40-0,73208-70-5,83780-59-0,92077-90-2,92077-91-3) → (S)-(+)-2-Tetrahydropyran-2-yloxypropan-1-ol (3539-39-7,76946-21-9,83780-60-3,92077-92-4,92077-93-5,124508-75-4,124508-76-5)

Guidance literature:

With lithium aluminium tetrahydride; In diethyl ether; at 0 ℃; for 1h;

DOI:10.1039/P19900002501

upstream raw materials:

Ethyl (S)-(-)-2-tetrahydropyran-2-yloxypropionate

3,4-dihydro-2H-pyran

ethyl (2S)-2-(tetrahydropyran-2-yloxy)propionate

3-(3-Chloro-2-hydroxy-phenyl)-4-methyl-4H-pyrano[3,2-c]chromen-5-one

Downstream raw materials:

(S,S)-(+)-bis(2-hydroxypropyl) ether

(S)-1,2-Propanediol

(2S)-2-hydroxypropyl 4-methylbenzenesulfonate

(2S)-2-(tetrahydro-2H-pyran-2-yloxy)propyl 4-methylbenzenesulfonate