1-iodo-3-phenylimidazo[1,5-a]pyridine

Base Information

• Chemical Name: 1-iodo-3-phenylimidazo[1,5-a]pyridine
• CAS No.: 906668-42-6
• Molecular Formula: C₁₃H₉IN₂
• Molecular Weight: 320.132
• Mol file: 906668-42-6.mol

Synonyms:1-iodo-3-phenylimidazo[1,5-a]pyridine

Chemical Property of 1-iodo-3-phenylimidazo[1,5-a]pyridine

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
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MSDS Files:

Useful:

Technology Process of 1-iodo-3-phenylimidazo[1,5-a]pyridine

There total 4 articles about 1-iodo-3-phenylimidazo[1,5-a]pyridine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

3-phenylimidazo[1,5-a]pyridine (35854-46-7) → 1-iodo-3-phenylimidazo[1,5-a]pyridine (906668-42-6)

Guidance literature:

With N-iodo-succinimide; In acetonitrile; at 25 ℃; for 3h;

DOI:10.1039/d1ra05417a

Reference yield: 41.0%

α-picoline (109-06-8) + benzylamine (100-46-9) → 1-iodo-3-phenylimidazo[1,5-a]pyridine (906668-42-6)

Guidance literature:

With copper(l) iodide; iodine; oxygen; acetic acid; In chlorobenzene; at 120 ℃; for 24h; under 760.051 Torr;

DOI:10.1002/ejoc.201800628

Reference yield:

2-(Aminomethyl)pyridine (3731-51-9) → 1-iodo-3-phenylimidazo[1,5-a]pyridine (906668-42-6)

Guidance literature:

Multi-step reaction with 2 steps

1: iodine; tert.-butylhydroperoxide / N,N-dimethyl-formamide / 70 °C

2: N-iodo-succinimide / acetonitrile / 3 h / 25 °C

With tert.-butylhydroperoxide; N-iodo-succinimide; iodine; In N,N-dimethyl-formamide; acetonitrile;

DOI:10.1039/d1ra05417a

upstream raw materials:

3-phenylimidazo[1,5-a]pyridine

α-picoline

benzylamine

2-(Aminomethyl)pyridine

Downstream raw materials:

1-(2-thienyl)-3-phenylimidazo[1,5-a]pyridine

1-phenyl-3-phenylimidazo[1,5-a]pyridine

1-(4-methoxylphenyl)-3-phenylimidazo[1,5-a]pyridine

3-phenylimidazo[1,5-a]pyridine