acetic acid 1-(toluene-4-sulfonyl)-2,5-dihydro-1H-pyrrol-3-ylmethyl ester

Base Information

• Chemical Name: acetic acid 1-(toluene-4-sulfonyl)-2,5-dihydro-1H-pyrrol-3-ylmethyl ester
• CAS No.: 935553-10-9
• Molecular Formula: C₁₄H₁₇NO₄S
• Molecular Weight: 295.359

Synonyms:acetic acid 1-(toluene-4-sulfonyl)-2,5-dihydro-1H-pyrrol-3-ylmethyl ester

Chemical Property of acetic acid 1-(toluene-4-sulfonyl)-2,5-dihydro-1H-pyrrol-3-ylmethyl ester

Chemical Property:

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Technology Process of acetic acid 1-(toluene-4-sulfonyl)-2,5-dihydro-1H-pyrrol-3-ylmethyl ester

There total 3 articles about acetic acid 1-(toluene-4-sulfonyl)-2,5-dihydro-1H-pyrrol-3-ylmethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

Acetic acid 2-{[allyl-(toluene-4-sulfonyl)-amino]-methyl}-allyl ester (120702-33-2) → acetic acid 1-(toluene-4-sulfonyl)-2,5-dihydro-1H-pyrrol-3-ylmethyl ester (935553-10-9)

Guidance literature:

Grubbs catalyst first generation; In dichloromethane; for 2h; Heating;

DOI:10.1021/jo0624896

Reference yield:

4-methyl-N-(2-propenyl)benzenesulfonamide (50487-71-3) → acetic acid 1-(toluene-4-sulfonyl)-2,5-dihydro-1H-pyrrol-3-ylmethyl ester (935553-10-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 80 percent / sodium hydride / dimethylformamide; various solvent(s) / 16 h / 20 °C

2: 77 percent / first generation Grubbs' catalyst / CH₂Cl₂ / 2 h / Heating

With sodium hydride; Grubbs catalyst first generation; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1021/jo0624896

Reference yield:

3-bromo-2-acetoxymethylpropene (130239-36-0) → acetic acid 1-(toluene-4-sulfonyl)-2,5-dihydro-1H-pyrrol-3-ylmethyl ester (935553-10-9)

Guidance literature:

Multi-step reaction with 2 steps

1: 80 percent / sodium hydride / dimethylformamide; various solvent(s) / 16 h / 20 °C

2: 77 percent / first generation Grubbs' catalyst / CH₂Cl₂ / 2 h / Heating

With sodium hydride; Grubbs catalyst first generation; In dichloromethane; N,N-dimethyl-formamide;

DOI:10.1021/jo0624896

upstream raw materials:

Acetic acid 2-{[allyl-(toluene-4-sulfonyl)-amino]-methyl}-allyl ester

4-methyl-N-(2-propenyl)benzenesulfonamide

3-bromo-2-acetoxymethylpropene

Downstream raw materials:

3-methyl-1-[(4-methylphenyl)-sulfonyl]-2,5-dihydro-1H-pyrrole

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