2-(Pyridin-4-YL)propan-2-amine

Base Information

• Chemical Name: 2-(Pyridin-4-YL)propan-2-amine
• CAS No.: 566155-76-8
• Molecular Formula: C₈H₁₂N₂
• Molecular Weight: 136.197
• Hs Code.: 2933399090
• European Community (EC) Number: 831-126-1
• DSSTox Substance ID: DTXSID90502523
• Mol file: 566155-76-8.mol

Synonyms:566155-76-8;2-(4-PYRIDYL)-2-PROPYLAMINE;2-(PYRIDIN-4-YL)PROPAN-2-AMINE;2-pyridin-4-ylpropan-2-amine;4-PYRIDINEMETHANAMINE, ALPHA,ALPHA-DIMETHYL-;MFCD08729286;ALPHA,ALPHA-DIMETHYL-4-PYRIDINEMETHANAMINE;SCHEMBL1515567;2-(4-Pyridinyl)-2-propanamine;DTXSID90502523;TQP1162;AKOS006291048;AB48742;AS-47941;SY011554;CS-0205491;EN300-223541;F17065;A869890

Chemical Property of 2-(Pyridin-4-YL)propan-2-amine

Chemical Property:

• Boiling Point: 236.847 °C at 760 mmHg
• Flash Point: 117.673 °C
• PSA: 38.91000
• Density: 0.998 g/cm³
• LogP: 1.97570
• Storage Temp.: 2-8°C
• XLogP3: 0.3
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 2
• Rotatable Bond Count: 1
• Exact Mass: 136.100048391
• Heavy Atom Count: 10
• Complexity: 104

Purity/Quality:

98%Min ^*data from raw suppliers

2-(4-Pyridyl)-2-propylamine ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: CC(C)(C1=CC=NC=C1)N

Technology Process of 2-(Pyridin-4-YL)propan-2-amine

There total 3 articles about 2-(Pyridin-4-YL)propan-2-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

pyridine-4-carbonitrile (100-48-1) + methyllithium (917-54-4) → 1-methyl-1-pyridin-4-ylethylamine (566155-76-8)

Guidance literature:

methyllithium; With cerium(III) chloride; In tetrahydrofuran; diethyl ether; at -78 ℃; for 0.5h; Inert atmosphere;

pyridine-4-carbonitrile; In tetrahydrofuran; diethyl ether; at -78 - 20 ℃; for 4h; Inert atmosphere;

DOI:10.1021/ml4004952

Reference yield: 28.0%

pyridine-4-carbonitrile (100-48-1) + methylmagnesium bromide (75-16-1) → 1-methyl-1-pyridin-4-ylethylamine (566155-76-8)

Guidance literature:

pyridine-4-carbonitrile; methylmagnesium bromide; In tetrahydrofuran; diethyl ether; at 0 - 20 ℃; for 0.5h;

With titanium(IV) isopropylate; In tetrahydrofuran; diethyl ether; at 50 ℃; for 16h;

Reference yield:

→ 1-methyl-1-pyridin-4-ylethylamine (566155-76-8)

Guidance literature:

4-(Ph-CH=N-C(Me)2-)-Pyridin, 2,4-Dinitrophenylhydrazin, A., W., HOAc, Δ;

upstream raw materials:

pyridine-4-carbonitrile

methyllithium

methylmagnesium bromide

Downstream raw materials:

N-[(1S,2R)-1-benzyl-2-hydroxy-3-(1-methyl-1-pyridin-4-ylethylamino)propyl]-5-piperidin-1-yl-N',N'-dipropylisophthalamide

Refernces

• 1、 -. "NITROGEN-CONTAINING SATURATED HETEROCYCLIC COMPOUND". Paragraph 0344. . Retrieved 2016/08/29.
• 2、 -. "PYRIDAZINONE DERIVATIVES AND USE THEREOF AS P2X7 RECEPTOR INHIBITORS". Page/Page column 138-140. . Retrieved 2009/06/27.