2,2-Dimethyl-propionic acid 2-[(1R,3S,3aS,4S,5R,7aR)-5-benzyloxy-1-((R)-1,5-dimethyl-hexyl)-3-(2-methoxy-ethoxymethoxy)-7a-methyl-octahydro-inden-4-yl]-ethyl ester

Base Information

Chemical Name:2,2-Dimethyl-propionic acid 2-[(1R,3S,3aS,4S,5R,7aR)-5-benzyloxy-1-((R)-1,5-dimethyl-hexyl)-3-(2-methoxy-ethoxymethoxy)-7a-methyl-octahydro-inden-4-yl]-ethyl ester
CAS No.:263340-90-5
Molecular Formula:C₃₆H₆₀O₆
Molecular Weight:588.869
Hs Code.:

2,2-Dimethyl-propionic acid 2-[(1R,3S,3aS,4S,5R,7aR)-5-benzyloxy-1-((R)-1,5-dimethyl-hexyl)-3-(2-methoxy-ethoxymethoxy)-7a-methyl-octahydro-inden-4-yl]-ethyl ester

Synonyms:2,2-Dimethyl-propionic acid 2-[(1R,3S,3aS,4S,5R,7aR)-5-benzyloxy-1-((R)-1,5-dimethyl-hexyl)-3-(2-methoxy-ethoxymethoxy)-7a-methyl-octahydro-inden-4-yl]-ethyl ester

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Chemical Property of 2,2-Dimethyl-propionic acid 2-[(1R,3S,3aS,4S,5R,7aR)-5-benzyloxy-1-((R)-1,5-dimethyl-hexyl)-3-(2-methoxy-ethoxymethoxy)-7a-methyl-octahydro-inden-4-yl]-ethyl ester

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Technology Process of 2,2-Dimethyl-propionic acid 2-[(1R,3S,3aS,4S,5R,7aR)-5-benzyloxy-1-((R)-1,5-dimethyl-hexyl)-3-(2-methoxy-ethoxymethoxy)-7a-methyl-octahydro-inden-4-yl]-ethyl ester

There total 16 articles about 2,2-Dimethyl-propionic acid 2-[(1R,3S,3aS,4S,5R,7aR)-5-benzyloxy-1-((R)-1,5-dimethyl-hexyl)-3-(2-methoxy-ethoxymethoxy)-7a-methyl-octahydro-inden-4-yl]-ethyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 62.0%

: 100-39-0
benzyl bromide

: 263340-82-5
2,2-Dimethyl-propionic acid 2-[(1R,3S,3aS,4S,5R,7aR)-1-((R)-1,5-dimethyl-hexyl)-5-hydroxy-3-(2-methoxy-ethoxymethoxy)-7a-methyl-octahydro-inden-4-yl]-ethyl ester

: 263340-90-5
2,2-Dimethyl-propionic acid 2-[(1R,3S,3aS,4S,5R,7aR)-5-benzyloxy-1-((R)-1,5-dimethyl-hexyl)-3-(2-methoxy-ethoxymethoxy)-7a-methyl-octahydro-inden-4-yl]-ethyl ester

Guidance literature:: With tetra-(n-butyl)ammonium iodide; sodium hydride; In tetrahydrofuran; for 2h; Heating;
DOI:10.1002/(SICI)1099-0690(200002)2000:3<439::AID-EJOC439>3.0.CO;2-F

Reference yield:

: 66251-18-1
Grundmann's ketone

: 263340-90-5
2,2-Dimethyl-propionic acid 2-[(1R,3S,3aS,4S,5R,7aR)-5-benzyloxy-1-((R)-1,5-dimethyl-hexyl)-3-(2-methoxy-ethoxymethoxy)-7a-methyl-octahydro-inden-4-yl]-ethyl ester

Guidance literature:: Multi-step reaction with 16 steps

1.1: LiI; HN(TMS)2 / CH₂Cl₂ / 3 h

2.1: 84 percent / tetrahydrofuran; pyridine / 0.5 h / -78 °C

3.1: 83 percent / MCPBA / CH₂Cl₂ / 0.5 h

4.1: 80 percent / NaBH₄; CeCl₃*7H₂O / methanol / 1 h

5.1: 90 percent / NaH; tetrabutylammonium iodide / tetrahydrofuran / 3 h / Heating

6.1: BH₃*SMe₂ / tetrahydrofuran / 3 h / 20 °C

6.2: 62 percent / H₂O₂; NaOH / ethanol; H₂O / 1 h / Heating

7.1: 91 percent / iPr₂EtN / CH₂Cl₂ / 3 h / 20 °C

8.1: 100 percent / H₂ / Pd/C / ethanol / 1.5 h

9.1: 97 percent / PDC; 4-Angstroem molecular sieves / CH₂Cl₂ / 2 h

10.1: 90 percent / LiN(TMS)2 / tetrahydrofuran / 2 h / 20 °C

11.1: 80 percent / LiCl / Pd(PPh₃)4 / tetrahydrofuran / 4 h / Heating

12.1: 87 percent / O₂; 5,10,15,20-tetraphenyl-21H,23H-porphine / CH₂Cl₂ / 2 h / -78 °C / Irradiation

13.1: 100 percent / NaNO₂; H₂ / PtO₂ / ethanol / 3 h

14.1: 86 percent / H₂; NaNO₂ / Pt/C / ethyl acetate / 2 h

15.1: 79 percent / pyridine; DMAP / CH₂Cl₂ / 1.5 h

16.1: 62 percent / NaH; TBAI / tetrahydrofuran / 2 h / Heating

With pyridine; dmap; sodium tetrahydroborate; dipyridinium dichromate; cerium(III) chloride; dimethylsulfide borane complex; 4 A molecular sieve; hydrogen; oxygen; 5,15,10,20-tetraphenylporphyrin; tetra-(n-butyl)ammonium iodide; sodium hydride; N-ethyl-N,N-diisopropylamine; 3-chloro-benzenecarboperoxoic acid; 1,1,1,3,3,3-hexamethyl-disilazane; lithium chloride; lithium iodide; lithium hexamethyldisilazane; sodium nitrite; platinum(IV) oxide; palladium on activated charcoal; platinum on activated charcoal; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; pyridine; methanol; ethanol; dichloromethane; ethyl acetate; 1.1: Silylation / 2.1: Selenenylation / 3.1: Elimination / 4.1: Reduction / 5.1: Etherification / 6.1: Hydroboration / 6.2: Oxidation / 7.1: Etherification / 8.1: Hydrogenolysis / 9.1: Oxidation / 10.1: Substitution / 11.1: Vinylation; Stille coupling / 12.1: Cycloaddition / 13.1: Adam's reduction / 14.1: Hydrogenation / 15.1: Acylation / 16.1: Benzylation;
DOI:10.1002/(SICI)1099-0690(200002)2000:3<439::AID-EJOC439>3.0.CO;2-F

Reference yield:

: 93922-90-8
De-A,B-cholest-14-en-8-one

: 263340-90-5
2,2-Dimethyl-propionic acid 2-[(1R,3S,3aS,4S,5R,7aR)-5-benzyloxy-1-((R)-1,5-dimethyl-hexyl)-3-(2-methoxy-ethoxymethoxy)-7a-methyl-octahydro-inden-4-yl]-ethyl ester

Guidance literature:: Multi-step reaction with 13 steps

1.1: 80 percent / NaBH₄; CeCl₃*7H₂O / methanol / 1 h

2.1: 90 percent / NaH; tetrabutylammonium iodide / tetrahydrofuran / 3 h / Heating

3.1: BH₃*SMe₂ / tetrahydrofuran / 3 h / 20 °C

3.2: 62 percent / H₂O₂; NaOH / ethanol; H₂O / 1 h / Heating

4.1: 91 percent / iPr₂EtN / CH₂Cl₂ / 3 h / 20 °C

5.1: 100 percent / H₂ / Pd/C / ethanol / 1.5 h

6.1: 97 percent / PDC; 4-Angstroem molecular sieves / CH₂Cl₂ / 2 h

7.1: 90 percent / LiN(TMS)2 / tetrahydrofuran / 2 h / 20 °C

8.1: 80 percent / LiCl / Pd(PPh₃)4 / tetrahydrofuran / 4 h / Heating

9.1: 87 percent / O₂; 5,10,15,20-tetraphenyl-21H,23H-porphine / CH₂Cl₂ / 2 h / -78 °C / Irradiation

10.1: 100 percent / NaNO₂; H₂ / PtO₂ / ethanol / 3 h

11.1: 86 percent / H₂; NaNO₂ / Pt/C / ethyl acetate / 2 h

12.1: 79 percent / pyridine; DMAP / CH₂Cl₂ / 1.5 h

13.1: 62 percent / NaH; TBAI / tetrahydrofuran / 2 h / Heating

With pyridine; dmap; sodium tetrahydroborate; dipyridinium dichromate; cerium(III) chloride; dimethylsulfide borane complex; 4 A molecular sieve; hydrogen; oxygen; 5,15,10,20-tetraphenylporphyrin; tetra-(n-butyl)ammonium iodide; sodium hydride; N-ethyl-N,N-diisopropylamine; lithium chloride; lithium hexamethyldisilazane; sodium nitrite; platinum(IV) oxide; palladium on activated charcoal; platinum on activated charcoal; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; methanol; ethanol; dichloromethane; ethyl acetate; 1.1: Reduction / 2.1: Etherification / 3.1: Hydroboration / 3.2: Oxidation / 4.1: Etherification / 5.1: Hydrogenolysis / 6.1: Oxidation / 7.1: Substitution / 8.1: Vinylation; Stille coupling / 9.1: Cycloaddition / 10.1: Adam's reduction / 11.1: Hydrogenation / 12.1: Acylation / 13.1: Benzylation;
DOI:10.1002/(SICI)1099-0690(200002)2000:3<439::AID-EJOC439>3.0.CO;2-F