6-Nitropyridin-2-amine

Base Information

• Chemical Name: 6-Nitropyridin-2-amine
• CAS No.: 14916-63-3
• Molecular Formula: C5H5N3O2
• Molecular Weight: 139.114
• Hs Code.: 2933399090
• DSSTox Substance ID: DTXSID80376538
• Nikkaji Number: J1.999.156C
• Wikidata: Q72440142
• Mol file: 14916-63-3.mol

Synonyms:6-nitropyridin-2-amine;14916-63-3;2-Amino-6-nitropyridine;2-Amino-6-nitro-pyridine;6-nitro-pyridin-2-ylamine;2-PYRIDINAMINE, 6-NITRO-;MFCD04114202;6-nitro-2-pyridinamine;SCHEMBL1923472;DTXSID80376538;JMAGBGSWLILKOC-UHFFFAOYSA-N;BBL103021;STL556830;AKOS006339166;AKOS007929964;AB17978;AC-5027;CS-W005434;DS-11155;SY047067;FT-0649580;A808851;J-518964

Chemical Property of 6-Nitropyridin-2-amine

Chemical Property:

• Vapor Pressure: 1.31E-05mmHg at 25°C
• Refractive Index: 1.645
• Boiling Point: 368.05 °C at 760 mmHg
• PKA: 0.83±0.10(Predicted)
• Flash Point: 176.39 °C
• PSA: 84.73000
• Density: 1.437 g/cm³
• LogP: 1.67640
• Storage Temp.: under inert gas (nitrogen or Argon) at 2–8 °C
• XLogP3: 0.7
• Hydrogen Bond Donor Count: 1
• Hydrogen Bond Acceptor Count: 4
• Rotatable Bond Count: 0
• Exact Mass: 139.038176411
• Heavy Atom Count: 10
• Complexity: 133

Purity/Quality:

99% ^*data from raw suppliers

2-AMINO-6-NITROPYRIDINE ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

• Canonical SMILES: C1=CC(=NC(=C1)[N+](=O)[O-])N

Technology Process of 6-Nitropyridin-2-amine

There total 1 articles about 6-Nitropyridin-2-amine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

2-Isocyanato-6-nitro-pyridine → 2-Amino-6-nitropyridine (14916-63-3)

Guidance literature:

With hydrogenchloride; In benzene; for 1h; Yield given; Heating;

DOI:10.1007/BF00506847

Reference yield: 91.0%

2-Amino-6-nitropyridine (14916-63-3) + chloroacetyl chloride (79-04-9) → 2-chloro-N-(2-(6-nitro)pyridinyl)acetamide

Guidance literature:

With triethylamine; In tetrahydrofuran; at 20 ℃;

DOI:10.1016/S0968-0896(03)00225-6

Reference yield: 80.0%

3-methoxyphenyl bromide (2398-37-0) + 2-Amino-6-nitropyridine (14916-63-3) → N-(3-methoxyphenyl)-6-nitropyridin-2-amine

Guidance literature:

3-methoxyphenyl bromide; With palladium diacetate; caesium carbonate; 4,5-bis(diphenylphosphino)-9,9-dimethylxanthene; In 1,4-dioxane; at 75 ℃; for 0.333333h; Schlenk technique; Inert atmosphere;

2-Amino-6-nitropyridine; In 1,4-dioxane; at 105 ℃; for 0.5h; Inert atmosphere; Schlenk technique;

DOI:10.3390/molecules25102309

Downstream raw materials:

2-nitro-6-chloro-pyridine

6-nitro-2-picrylaminopyridine

(R)-N-[4-{2-aminopyrid-6-ylsulphonyl}-2,3-dichlorophenyl]-2-hydroxy-2-methyl-3,3,3-trifluoropropanamide

(R)-N-[4-{2-nitropyridyl}-6-sulphonyl-2,3,dichlorophenyl]-2-hydroxy-2-methyl-3,3,3-trifluoropropanamide

Refernces