2-(3,5-bis-trifluoromethyl-phenyl)-pent-4-enoic acid (8-phenyl-1,4-dioxa-spiro[4.5]dec-8-yl)-amide

Base Information

• Chemical Name: 2-(3,5-bis-trifluoromethyl-phenyl)-pent-4-enoic acid (8-phenyl-1,4-dioxa-spiro[4.5]dec-8-yl)-amide
• CAS No.: 479195-03-4
• Molecular Formula: C₂₇H₂₇F₆NO₃
• Molecular Weight: 527.507
• Mol file: 479195-03-4.mol

Synonyms:2-(3,5-bis-trifluoromethyl-phenyl)-pent-4-enoic acid (8-phenyl-1,4-dioxa-spiro[4.5]dec-8-yl)-amide

Chemical Property of 2-(3,5-bis-trifluoromethyl-phenyl)-pent-4-enoic acid (8-phenyl-1,4-dioxa-spiro[4.5]dec-8-yl)-amide

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(3,5-bis-trifluoromethyl-phenyl)-pent-4-enoic acid (8-phenyl-1,4-dioxa-spiro[4.5]dec-8-yl)-amide

There total 4 articles about 2-(3,5-bis-trifluoromethyl-phenyl)-pent-4-enoic acid (8-phenyl-1,4-dioxa-spiro[4.5]dec-8-yl)-amide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.0%

(RS)-N-(4-oxo-1-phenylcyclohexyl)-α-(2-propenyl)-3,5-bis(trifluoromethyl)benzeneacetamide (374791-58-9) + ethylene glycol (107-21-1) → 2-(3,5-bis-trifluoromethyl-phenyl)-pent-4-enoic acid (8-phenyl-1,4-dioxa-spiro[4.5]dec-8-yl)-amide (479195-03-4)

Guidance literature:

With toluene-4-sulfonic acid; In toluene;

DOI:10.1016/j.bmcl.2005.11.111

Reference yield:

2-(3,5-bis-trifluoromethyl-phenyl)-pent-4-enoyl chloride (877056-25-2) → 2-(3,5-bis-trifluoromethyl-phenyl)-pent-4-enoic acid (8-phenyl-1,4-dioxa-spiro[4.5]dec-8-yl)-amide (479195-03-4)

Guidance literature:

Multi-step reaction with 2 steps

1: 60 percent / pyridine / CH₂Cl₂

2: 98 percent / p-TSA / toluene

With pyridine; toluene-4-sulfonic acid; In dichloromethane; toluene;

DOI:10.1016/j.bmcl.2005.11.111

Reference yield:

(RS)-α-(2-propenyl)-3,5-bis(trifluoromethyl)benzeneacetic acid (334477-38-2) → 2-(3,5-bis-trifluoromethyl-phenyl)-pent-4-enoic acid (8-phenyl-1,4-dioxa-spiro[4.5]dec-8-yl)-amide (479195-03-4)

Guidance literature:

Multi-step reaction with 3 steps

1: 100 percent / (CO₂Cl)2

2: 60 percent / pyridine / CH₂Cl₂

3: 98 percent / p-TSA / toluene

With pyridine; (CO₂Cl)2; toluene-4-sulfonic acid; In dichloromethane; toluene;

DOI:10.1016/j.bmcl.2005.11.111

upstream raw materials:

(RS)-N-(4-oxo-1-phenylcyclohexyl)-α-(2-propenyl)-3,5-bis(trifluoromethyl)benzeneacetamide

ethylene glycol

2-(3,5-bis-trifluoromethyl-phenyl)-pent-4-enoyl chloride

(RS)-α-(2-propenyl)-3,5-bis(trifluoromethyl)benzeneacetic acid

Downstream raw materials:

3-(3,5-bis-trifluoromethyl-phenyl)-1-[4-(2-oxa-8-aza-spiro[4.5]dec-8-yl)-1-phenyl-cyclohexyl]-pyrrolidin-2-one

2-(3,5-bis-trifluoromethyl-phenyl)-4-bromo-N-(8-phenyl-1,4-dioxa-spiro[4.5]dec-8-yl)-butyramide

3-(3,5-bis-trifluoromethyl-phenyl)-3-methyl-1-(8-phenyl-1,4-dioxa-spiro[4.5]dec-8-yl)-pyrrolidin-2-one

3-(3,5-bis-trifluoromethyl-phenyl)-1-(8-phenyl-1,4-dioxa-spiro[4.5]dec-8-yl)-pyrrolidin-2-one