dimethyl (1S,2S,4S,5S)-4-(2-chlorophenylamino)-5-hydroxycyclohexane-1,2-dicarboxylate

Base Information

Chemical Name:dimethyl (1S,2S,4S,5S)-4-(2-chlorophenylamino)-5-hydroxycyclohexane-1,2-dicarboxylate
CAS No.:1254946-85-4
Molecular Formula:C₁₆H₂₀ClNO₅
Molecular Weight:341.791
Hs Code.:

Synonyms:dimethyl (1S,2S,4S,5S)-4-(2-chlorophenylamino)-5-hydroxycyclohexane-1,2-dicarboxylate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of dimethyl (1S,2S,4S,5S)-4-(2-chlorophenylamino)-5-hydroxycyclohexane-1,2-dicarboxylate

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Technology Process of dimethyl (1S,2S,4S,5S)-4-(2-chlorophenylamino)-5-hydroxycyclohexane-1,2-dicarboxylate

There total 1 articles about dimethyl (1S,2S,4S,5S)-4-(2-chlorophenylamino)-5-hydroxycyclohexane-1,2-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 91.0%

: 845870-02-2
C₁₀H₁₄O₅

: 95-51-2
o-chloroaniline

: 1254946-85-4
dimethyl (1S,2S,4S,5S)-4-(2-chlorophenylamino)-5-hydroxycyclohexane-1,2-dicarboxylate

Guidance literature:: With indium(III) bromide; In dichloromethane; at 20 ℃; for 2.5h;
DOI:10.1016/j.crci.2009.11.004

Reference yield: 85.0%

: 1254946-85-4
dimethyl (1S,2S,4S,5S)-4-(2-chlorophenylamino)-5-hydroxycyclohexane-1,2-dicarboxylate

: 69739-34-0
t-butyldimethylsiyl triflate

: 1254946-98-9
dimethyl (1S,2S,4S,5S)-4-(tert-butyldimethylsilyloxy)-5-(2-chlorophenylamino)cyclohexane-1,2-dicarboxylate

Guidance literature:: With 2,6-dimethylpyridine; In dichloromethane; at 0 - 20 ℃; for 2.5h; Inert atmosphere;
DOI:10.1016/j.crci.2009.11.004

Reference yield:

: 1254946-85-4
dimethyl (1S,2S,4S,5S)-4-(2-chlorophenylamino)-5-hydroxycyclohexane-1,2-dicarboxylate

: 1254946-99-0
dimethyl (1S,2S,4S,5S)-4-(1-(2-chlorophenyl)ureido)-5-hydroxycyclohexane-1,2-dicarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: 2,6-dimethylpyridine / dichloromethane / 2.5 h / 0 - 20 °C / Inert atmosphere

2: tetrahydrofuran / -10 °C / Inert atmosphere

With 2,6-dimethylpyridine; In tetrahydrofuran; dichloromethane;
DOI:10.1016/j.crci.2009.11.004