dimethyl (1S,2S,4S,5S)-4-hydroxy-5-(2-oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)cyclohexane-1,2-dicarboxylate

Base Information

Chemical Name:dimethyl (1S,2S,4S,5S)-4-hydroxy-5-(2-oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)cyclohexane-1,2-dicarboxylate
CAS No.:1254947-00-6
Molecular Formula:C₁₇H₂₀N₂O₆
Molecular Weight:348.356
Hs Code.:

Synonyms:dimethyl (1S,2S,4S,5S)-4-hydroxy-5-(2-oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)cyclohexane-1,2-dicarboxylate

Suppliers and Price of dimethyl (1S,2S,4S,5S)-4-hydroxy-5-(2-oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)cyclohexane-1,2-dicarboxylate

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of dimethyl (1S,2S,4S,5S)-4-hydroxy-5-(2-oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)cyclohexane-1,2-dicarboxylate

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of dimethyl (1S,2S,4S,5S)-4-hydroxy-5-(2-oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)cyclohexane-1,2-dicarboxylate

There total 5 articles about dimethyl (1S,2S,4S,5S)-4-hydroxy-5-(2-oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)cyclohexane-1,2-dicarboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 51.0%

: 1254946-99-0
dimethyl (1S,2S,4S,5S)-4-(1-(2-chlorophenyl)ureido)-5-hydroxycyclohexane-1,2-dicarboxylate

: 1254947-00-6
dimethyl (1S,2S,4S,5S)-4-hydroxy-5-(2-oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)cyclohexane-1,2-dicarboxylate

Guidance literature:: With palladium diacetate; N-ethyl-N,N-diisopropylamine; XPhos; In isopropyl alcohol; at 83 ℃; for 24h; Inert atmosphere;
DOI:10.1016/j.crci.2009.11.004

Reference yield:

: 845870-02-2
C₁₀H₁₄O₅

: 1254947-00-6
dimethyl (1S,2S,4S,5S)-4-hydroxy-5-(2-oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)cyclohexane-1,2-dicarboxylate

Guidance literature:: Multi-step reaction with 4 steps

1: indium(III) bromide / dichloromethane / 2.5 h / 20 °C

2: 2,6-dimethylpyridine / dichloromethane / 2.5 h / 0 - 20 °C / Inert atmosphere

3: tetrahydrofuran / -10 °C / Inert atmosphere

4: palladium diacetate; N-ethyl-N,N-diisopropylamine; XPhos / isopropyl alcohol / 24 h / 83 °C / Inert atmosphere

With 2,6-dimethylpyridine; indium(III) bromide; palladium diacetate; N-ethyl-N,N-diisopropylamine; XPhos; In tetrahydrofuran; dichloromethane; isopropyl alcohol;
DOI:10.1016/j.crci.2009.11.004

Reference yield:

: 1254946-98-9
dimethyl (1S,2S,4S,5S)-4-(tert-butyldimethylsilyloxy)-5-(2-chlorophenylamino)cyclohexane-1,2-dicarboxylate

: 1254947-00-6
dimethyl (1S,2S,4S,5S)-4-hydroxy-5-(2-oxo-2,3-dihydro-1H-benzo[d]imidazol-1-yl)cyclohexane-1,2-dicarboxylate

Guidance literature:: Multi-step reaction with 2 steps

1: tetrahydrofuran / -10 °C / Inert atmosphere

2: palladium diacetate; N-ethyl-N,N-diisopropylamine; XPhos / isopropyl alcohol / 24 h / 83 °C / Inert atmosphere

With palladium diacetate; N-ethyl-N,N-diisopropylamine; XPhos; In tetrahydrofuran; isopropyl alcohol;
DOI:10.1016/j.crci.2009.11.004