{2-[(1R,2R,3aS,7aS)-1-((E)-4-Methyl-3-oxo-4-phenoxy-pent-1-enyl)-2-(tetrahydro-pyran-2-yloxy)-2,3,3a,6,7,7a-hexahydro-1H-inden-5-yl]-ethoxy}-acetic acid tert-butyl ester

Base Information

Chemical Name:{2-[(1R,2R,3aS,7aS)-1-((E)-4-Methyl-3-oxo-4-phenoxy-pent-1-enyl)-2-(tetrahydro-pyran-2-yloxy)-2,3,3a,6,7,7a-hexahydro-1H-inden-5-yl]-ethoxy}-acetic acid tert-butyl ester
CAS No.:127127-89-3
Molecular Formula:C₃₄H₄₈O₇
Molecular Weight:568.751
Hs Code.:

{2-[(1R,2R,3aS,7aS)-1-((E)-4-Methyl-3-oxo-4-phenoxy-pent-1-enyl)-2-(tetrahydro-pyran-2-yloxy)-2,3,3a,6,7,7a-hexahydro-1H-inden-5-yl]-ethoxy}-acetic acid tert-butyl ester

Synonyms:{2-[(1R,2R,3aS,7aS)-1-((E)-4-Methyl-3-oxo-4-phenoxy-pent-1-enyl)-2-(tetrahydro-pyran-2-yloxy)-2,3,3a,6,7,7a-hexahydro-1H-inden-5-yl]-ethoxy}-acetic acid tert-butyl ester

Suppliers and Price of {2-[(1R,2R,3aS,7aS)-1-((E)-4-Methyl-3-oxo-4-phenoxy-pent-1-enyl)-2-(tetrahydro-pyran-2-yloxy)-2,3,3a,6,7,7a-hexahydro-1H-inden-5-yl]-ethoxy}-acetic acid tert-butyl ester

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 0 raw suppliers

Chemical Property of {2-[(1R,2R,3aS,7aS)-1-((E)-4-Methyl-3-oxo-4-phenoxy-pent-1-enyl)-2-(tetrahydro-pyran-2-yloxy)-2,3,3a,6,7,7a-hexahydro-1H-inden-5-yl]-ethoxy}-acetic acid tert-butyl ester

Chemical Property:

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Technology Process of {2-[(1R,2R,3aS,7aS)-1-((E)-4-Methyl-3-oxo-4-phenoxy-pent-1-enyl)-2-(tetrahydro-pyran-2-yloxy)-2,3,3a,6,7,7a-hexahydro-1H-inden-5-yl]-ethoxy}-acetic acid tert-butyl ester

There total 15 articles about {2-[(1R,2R,3aS,7aS)-1-((E)-4-Methyl-3-oxo-4-phenoxy-pent-1-enyl)-2-(tetrahydro-pyran-2-yloxy)-2,3,3a,6,7,7a-hexahydro-1H-inden-5-yl]-ethoxy}-acetic acid tert-butyl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 40665-74-5
dimethyl 3-methyl-3-phenoxy-2-oxo-butylphosphonate

: 127127-88-2
{2-[(1R,2R,3aS,7aS)-1-Formyl-2-(tetrahydro-pyran-2-yloxy)-2,3,3a,6,7,7a-hexahydro-1H-inden-5-yl]-ethoxy}-acetic acid tert-butyl ester

: 127127-89-3
{2-[(1R,2R,3aS,7aS)-1-((E)-4-Methyl-3-oxo-4-phenoxy-pent-1-enyl)-2-(tetrahydro-pyran-2-yloxy)-2,3,3a,6,7,7a-hexahydro-1H-inden-5-yl]-ethoxy}-acetic acid tert-butyl ester

Guidance literature:: With sodium hydride; In tetrahydrofuran; Ambient temperature;
DOI:10.1248/cpb.37.1647

Reference yield:

: 65025-95-8
(3aR,4S,5R,6aS)-4-({[dimethyl(2-methyl-2-propanyl)silyl]oxy}methyl)-5-(tetrahydro-2H-pyran-2-yloxy)hexahydro-2H-cyclopenta[b]furan-2-one

: 127127-89-3
{2-[(1R,2R,3aS,7aS)-1-((E)-4-Methyl-3-oxo-4-phenoxy-pent-1-enyl)-2-(tetrahydro-pyran-2-yloxy)-2,3,3a,6,7,7a-hexahydro-1H-inden-5-yl]-ethoxy}-acetic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 15 steps

1: DIBAH / toluene / -78 °C

2: toluene / 60 °C

3: H₂ / 10percent Pd/C / methanol / Ambient temperature

4: (COCl)2, DMSO, Et₃N / CH₂Cl₂ / -78 °C

5: Zn, TiCl₄ / Ambient temperature

6: 100 percent / Siam₂BH / tetrahydrofuran / 0 °C

7: LiAlH₄ / tetrahydrofuran / 0 °C

8: (COCl)2, DMSO, Et₃N / CH₂Cl₂ / -78 °C

9: (PhCH₂)2NH₂(+)*TFA(-) / benzene / 60 °C

10: tBuOK / tetrahydrofuran / Ambient temperature

11: 9-BBN / tetrahydrofuran / 0 °C

12: 50percent aq. NaOH / Bu₄N*HSO₄ / CH₂Cl₂ / 40 °C

13: Bu₄NF / tetrahydrofuran / Ambient temperature

14: SO₃*Py, Et₃N / dimethylsulfoxide / Ambient temperature

15: 90 percent / NaH / tetrahydrofuran / Ambient temperature

With sodium hydroxide; lithium aluminium tetrahydride; 9-borabicyclo[3.3.1]nonane dimer; oxalyl dichloride; pyridine-SO₃ complex; potassium tert-butylate; tetrabutyl ammonium fluoride; hydrogen; bis-(1,2-dimethylpropyl)borane; titanium tetrachloride; sodium hydride; diisobutylaluminium hydride; dimethyl sulfoxide; triethylamine; zinc; dibenzylammonium trifluoroacetate salt; palladium on activated charcoal; tetra(n-butyl)ammonium hydrogensulfate; In tetrahydrofuran; methanol; dichloromethane; dimethyl sulfoxide; toluene; benzene;
DOI:10.1248/cpb.37.1647

Reference yield:

: 113428-34-5
(1S,2R,3aS,7aS)-1-(tert-Butyl-dimethyl-silanyloxymethyl)-2-(tetrahydro-pyran-2-yloxy)-2,3,3a,6,7,7a-hexahydro-1H-indene-5-carbaldehyde

: 127127-89-3
{2-[(1R,2R,3aS,7aS)-1-((E)-4-Methyl-3-oxo-4-phenoxy-pent-1-enyl)-2-(tetrahydro-pyran-2-yloxy)-2,3,3a,6,7,7a-hexahydro-1H-inden-5-yl]-ethoxy}-acetic acid tert-butyl ester

Guidance literature:: Multi-step reaction with 6 steps

1: tBuOK / tetrahydrofuran / Ambient temperature

2: 9-BBN / tetrahydrofuran / 0 °C

3: 50percent aq. NaOH / Bu₄N*HSO₄ / CH₂Cl₂ / 40 °C

4: Bu₄NF / tetrahydrofuran / Ambient temperature

5: SO₃*Py, Et₃N / dimethylsulfoxide / Ambient temperature

6: 90 percent / NaH / tetrahydrofuran / Ambient temperature

With sodium hydroxide; 9-borabicyclo[3.3.1]nonane dimer; pyridine-SO₃ complex; potassium tert-butylate; tetrabutyl ammonium fluoride; sodium hydride; triethylamine; tetra(n-butyl)ammonium hydrogensulfate; In tetrahydrofuran; dichloromethane; dimethyl sulfoxide;
DOI:10.1248/cpb.37.1647