Technology Process of (2S,3S,4R,5R,6R)-6-hydroxy-2,3,4,5-tetramethoxycyclohexanone
There total 3 articles about (2S,3S,4R,5R,6R)-6-hydroxy-2,3,4,5-tetramethoxycyclohexanone which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
With
2-pentafluorophenyl-6,7-dihydro-5H-pyrrolo[2,1-c][1,2,4]triazol-2-ium tetrafluoroborate; triethylamine;
In
1,2-dichloro-ethane;
at 40 ℃;
for 16h;
Inert atmosphere;
DOI:10.1021/jo500645z
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: toluene-4-sulfonic acid / dichloromethane; methanol / 18 h
2.1: dimethyl sulfoxide; oxalyl dichloride / dichloromethane / 0.42 h / -78 °C / Inert atmosphere
2.2: 1.5 h / -78 - 25 °C / Inert atmosphere
3.1: triethylamine; 2-pentafluorophenyl-6,7-dihydro-5H-pyrrolo[2,1-c][1,2,4]triazol-2-ium tetrafluoroborate / 1,2-dichloro-ethane / 16 h / 40 °C / Inert atmosphere
With
2-pentafluorophenyl-6,7-dihydro-5H-pyrrolo[2,1-c][1,2,4]triazol-2-ium tetrafluoroborate; oxalyl dichloride; toluene-4-sulfonic acid; dimethyl sulfoxide; triethylamine;
In
methanol; dichloromethane; 1,2-dichloro-ethane;
2.1: |Swern Oxidation / 2.2: |Swern Oxidation;
DOI:10.1021/jo500645z
- Guidance literature:
-
Multi-step reaction with 2 steps
1.1: dimethyl sulfoxide; oxalyl dichloride / dichloromethane / 0.42 h / -78 °C / Inert atmosphere
1.2: 1.5 h / -78 - 25 °C / Inert atmosphere
2.1: triethylamine; 2-pentafluorophenyl-6,7-dihydro-5H-pyrrolo[2,1-c][1,2,4]triazol-2-ium tetrafluoroborate / 1,2-dichloro-ethane / 16 h / 40 °C / Inert atmosphere
With
2-pentafluorophenyl-6,7-dihydro-5H-pyrrolo[2,1-c][1,2,4]triazol-2-ium tetrafluoroborate; oxalyl dichloride; dimethyl sulfoxide; triethylamine;
In
dichloromethane; 1,2-dichloro-ethane;
1.1: |Swern Oxidation / 1.2: |Swern Oxidation;
DOI:10.1021/jo500645z
