Technology Process of 2,3,4,5-tetra-O-methyl-1,6-di-O-trityl-D-mannitol
There total 1 articles about 2,3,4,5-tetra-O-methyl-1,6-di-O-trityl-D-mannitol which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
With
sodium hydride;
In
tetrahydrofuran; mineral oil;
at 25 ℃;
for 25h;
Inert atmosphere;
Reflux;
DOI:10.1021/jo500645z
- Guidance literature:
-
Multi-step reaction with 3 steps
1: 91 percent / H2 / 10 percent Pd/C / methanol; CH2Cl2 / 24 h / 2327.17 Torr
2: 90 percent / 60 percent HNO3 / H2O / 24 h / 70 - 80 °C
3: 18.77 g / DCC; DMAP / CH2Cl2 / 20 °C
With
dmap; hydrogen; nitric acid; dicyclohexyl-carbodiimide;
palladium on activated charcoal;
In
methanol; dichloromethane; water;
DOI:10.1016/S0008-6215(03)00093-4
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: toluene-4-sulfonic acid / dichloromethane; methanol / 18 h
2.1: dimethyl sulfoxide; oxalyl dichloride / dichloromethane / 0.42 h / -78 °C / Inert atmosphere
2.2: 1.5 h / -78 - 25 °C / Inert atmosphere
3.1: triethylamine; 2-pentafluorophenyl-6,7-dihydro-5H-pyrrolo[2,1-c][1,2,4]triazol-2-ium tetrafluoroborate / 1,2-dichloro-ethane / 16 h / 40 °C / Inert atmosphere
With
2-pentafluorophenyl-6,7-dihydro-5H-pyrrolo[2,1-c][1,2,4]triazol-2-ium tetrafluoroborate; oxalyl dichloride; toluene-4-sulfonic acid; dimethyl sulfoxide; triethylamine;
In
methanol; dichloromethane; 1,2-dichloro-ethane;
2.1: |Swern Oxidation / 2.2: |Swern Oxidation;
DOI:10.1021/jo500645z
