trans-O-(2-Hydroxycyclohexyl)-N-isopropylhydroxylamine Hydrochloride

Base Information

• Chemical Name: trans-O-(2-Hydroxycyclohexyl)-N-isopropylhydroxylamine Hydrochloride
• CAS No.: 74312-44-0
• Molecular Formula: C₉H₁₉NO₂*ClH
• Molecular Weight: 209.716
• Mol file: 74312-44-0.mol

Synonyms:trans-O-(2-Hydroxycyclohexyl)-N-isopropylhydroxylamine Hydrochloride

Chemical Property of trans-O-(2-Hydroxycyclohexyl)-N-isopropylhydroxylamine Hydrochloride

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of trans-O-(2-Hydroxycyclohexyl)-N-isopropylhydroxylamine Hydrochloride

There total 2 articles about trans-O-(2-Hydroxycyclohexyl)-N-isopropylhydroxylamine Hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

trans-1-(O-Acetoximino)cyclohexan-2-ol (74312-48-4) → trans-O-(2-Hydroxycyclohexyl)-N-isopropylhydroxylamine Hydrochloride (74312-44-0)

Guidance literature:

With hydrogen; Pt (PtO); In hydrogenchloride; ethanol; at 25 ℃; for 2.5h; under 2585.7 Torr;

DOI:10.1021/jo01306a039

Reference yield:

cyclohexane-1,2-epoxide (286-20-4) → trans-O-(2-Hydroxycyclohexyl)-N-isopropylhydroxylamine Hydrochloride (74312-44-0)

Guidance literature:

Multi-step reaction with 2 steps

1: NaH / 1) tert-Butyl alcohol, 10 min, 2) heating, 65 h

2: 90 percent / H₂ / Pt (PtO) / aq. HCl; ethanol / 2.5 h / 25 °C / 2585.7 Torr

With hydrogen; sodium hydride; Pt (PtO); In hydrogenchloride; ethanol;

DOI:10.1021/jo01306a039

Reference yield: 37.0%

trans-O-(2-Hydroxycyclohexyl)-N-isopropylhydroxylamine Hydrochloride (74312-44-0) + acetyl chloride (75-36-5) → trans-O-(2-Hydroxycyclohexyl)-N-acetyl-N-isopropylhydroxylamine (74312-47-3)

Guidance literature:

In pyridine; at 0 ℃; for 4h;

DOI:10.1021/jo01306a039

upstream raw materials:

trans-1-(O-Acetoximino)cyclohexan-2-ol

cyclohexane-1,2-epoxide

Downstream raw materials:

trans-O-(2-Hydroxycyclohexyl)-N-isopropylhydroxylamine

trans-O-(2-Hydroxycyclohexyl)-N-acetyl-N-isopropylhydroxylamine

trans-O-(2-Acetoxycyclohexyl)-N-isopropylhydroxylamine Hydrochloride

trans-O-(2-Acetoxycyclohexyl)-N-isopropylhydroxylamine