C₃₆H₃₆FNO₄

Base Information

• Chemical Name: C₃₆H₃₆FNO₄
• CAS No.: 1236278-84-4
• Molecular Formula: C₃₆H₃₆FNO₄
• Molecular Weight: 565.685
• Mol file: 1236278-84-4.mol

Synonyms:C₃₆H₃₆FNO₄

Chemical Property of C₃₆H₃₆FNO₄

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of C₃₆H₃₆FNO₄

There total 13 articles about C₃₆H₃₆FNO₄ which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 94.0%

(3R,4S,5S,6R)-6-[(N-benzyl-N-(benzyloxycarbonyl))amino]-3,5-bis(benzyloxy)-4-fluoro-1,8-nonadiene (1236278-83-3) → C36H36FNO4 (1236278-84-4)

Guidance literature:

With tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride; In dichloromethane; at 25 ℃; for 30h; Inert atmosphere;

DOI:10.1515/znb-2010-0402

Reference yield:

3-deoxy-3-fluoro-1,2-5,6-di-O-isopropylidene-α-D-glucofuranose → C36H36FNO4 (1236278-84-4)

Guidance literature:

Multi-step reaction with 9 steps

1.1: sulfuric acid; water / 24 h / 25 °C

2.1: hydrogenchloride / 8 h / 0 °C / Reflux

3.1: pyridine; dmap / 16 h / 25 °C

4.1: sodium hydride / N,N-dimethyl-formamide; mineral oil / 0.5 h / 0 - 25 °C

4.2: 3 h / 25 °C

5.1: toluene-4-sulfonic acid / methanol; dichloromethane / 24 h / 25 °C

6.1: 1H-imidazole; iodine; triphenylphosphine / toluene / 2 h / 95 °C

7.1: zinc

8.1: sodium hydrogencarbonate / dichloromethane / 14 h / 25 °C

9.1: tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride / dichloromethane / 30 h / 25 °C / Inert atmosphere

With pyridine; 1H-imidazole; tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride; hydrogenchloride; dmap; sulfuric acid; water; iodine; sodium hydride; sodium hydrogencarbonate; toluene-4-sulfonic acid; triphenylphosphine; zinc; In methanol; dichloromethane; N,N-dimethyl-formamide; toluene; mineral oil;

DOI:10.1515/znb-2010-0402

Reference yield:

benzylamine (100-46-9) → C36H36FNO4 (1236278-84-4)

Guidance literature:

Multi-step reaction with 3 steps

1: zinc

2: sodium hydrogencarbonate / dichloromethane / 14 h / 25 °C

3: tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride / dichloromethane / 30 h / 25 °C / Inert atmosphere

With tricyclohexylphosphine[1,3-bis(2,4,6-trimethylphenyl)-4,5-dihydroimidazol-2-ylidine][benzylidene]ruthenium(II) dichloride; sodium hydrogencarbonate; zinc; In dichloromethane;

DOI:10.1515/znb-2010-0402

upstream raw materials:

methyl 2,4-di-O-benzyl-3-deoxy-3-fluoro-β-D-glucopyranoside

methyl 2,4-di-O-benzyl-3,6-dideoxy-3-fluoro-6-iodo-β-D-glucopyranoside

(3R,4S,5S,6R)-6-[(N-benzyl)amino]-3,5-bis(benzyloxy)-4-fluoro-1,8-nonadiene

methyl 2,4-di-O-benzyl-3,6-dideoxy-3-fluoro-6-iodo-α-D-glucopyranoside

Downstream raw materials:

(1RS,3R,4S,5S,6R)-6-[(N-benzyl-N-(benzyloxycarbonyl))-amino]-3,5-bis(benzyloxy)-4-fluorocycloheptanol

(1RS,2R,3R,4S,5R)-5-[(N-benzyl-N-(benzyloxycarbonyl))amino]-2,4-bis(benzyloxy)-3-fluorocycloheptanol