4-(((4-(3-chlorophenyl)-6-fluoro-3-pyridinyl)methoxy)(1-methyl-1H-imidazol-5-yl)methyl)benzonitrile

Base Information

Chemical Name:4-(((4-(3-chlorophenyl)-6-fluoro-3-pyridinyl)methoxy)(1-methyl-1H-imidazol-5-yl)methyl)benzonitrile
CAS No.:450837-14-6
Molecular Formula:C₂₄H₁₈ClFN₄O
Molecular Weight:432.885
Hs Code.:

Synonyms:4-(((4-(3-chlorophenyl)-6-fluoro-3-pyridinyl)methoxy)(1-methyl-1H-imidazol-5-yl)methyl)benzonitrile

Suppliers and Price of 4-(((4-(3-chlorophenyl)-6-fluoro-3-pyridinyl)methoxy)(1-methyl-1H-imidazol-5-yl)methyl)benzonitrile

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 4-(((4-(3-chlorophenyl)-6-fluoro-3-pyridinyl)methoxy)(1-methyl-1H-imidazol-5-yl)methyl)benzonitrile

Chemical Property:

Purity/Quality:: 98% ^*data from raw suppliers

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Technology Process of 4-(((4-(3-chlorophenyl)-6-fluoro-3-pyridinyl)methoxy)(1-methyl-1H-imidazol-5-yl)methyl)benzonitrile

There total 5 articles about 4-(((4-(3-chlorophenyl)-6-fluoro-3-pyridinyl)methoxy)(1-methyl-1H-imidazol-5-yl)methyl)benzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 2369-19-9
2-fluoro-5-methylpyridine

: 450837-14-6
4-(((4-(3-chlorophenyl)-6-fluoro-3-pyridinyl)methoxy)(1-methyl-1H-imidazol-5-yl)methyl)benzonitrile

Guidance literature:: Multi-step reaction with 5 steps

1.1: LDA / tetrahydrofuran / -78 °C

1.2: 74 percent / I₂ / tetrahydrofuran / -78 - 20 °C

2.1: LDA / tetrahydrofuran / -78 °C

2.2: 90 percent / H₂O / tetrahydrofuran / -78 - 20 °C

3.1: 84 percent / Pd(PPh₃)4; aq. Na₂CO₃ / toluene; ethanol / Heating

4.1: NBS; benzoyl peroxide / CCl₄

5.1: Ag₂O / CH₂Cl₂

With N-Bromosuccinimide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; silver(l) oxide; lithium diisopropyl amide; dibenzoyl peroxide; In tetrahydrofuran; tetrachloromethane; ethanol; dichloromethane; toluene; 3.1: Suzuki coupling;
DOI:10.1016/j.bmcl.2004.07.004

Reference yield:

: 153034-94-7
2-Fluoro-4-iodo-5-methylpyridine

: 450837-14-6
4-(((4-(3-chlorophenyl)-6-fluoro-3-pyridinyl)methoxy)(1-methyl-1H-imidazol-5-yl)methyl)benzonitrile

Guidance literature:: Multi-step reaction with 3 steps

1: 84 percent / Pd(PPh₃)4; aq. Na₂CO₃ / toluene; ethanol / Heating

2: NBS; benzoyl peroxide / CCl₄

3: Ag₂O / CH₂Cl₂

With N-Bromosuccinimide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; silver(l) oxide; dibenzoyl peroxide; In tetrachloromethane; ethanol; dichloromethane; toluene; 1: Suzuki coupling;
DOI:10.1016/j.bmcl.2004.07.004

Reference yield:

: 153034-78-7
2-Fluoro-3-iodo-5-methylpyridine

: 450837-14-6
4-(((4-(3-chlorophenyl)-6-fluoro-3-pyridinyl)methoxy)(1-methyl-1H-imidazol-5-yl)methyl)benzonitrile

Guidance literature:: Multi-step reaction with 4 steps

1.1: LDA / tetrahydrofuran / -78 °C

1.2: 90 percent / H₂O / tetrahydrofuran / -78 - 20 °C

2.1: 84 percent / Pd(PPh₃)4; aq. Na₂CO₃ / toluene; ethanol / Heating

3.1: NBS; benzoyl peroxide / CCl₄

4.1: Ag₂O / CH₂Cl₂

With N-Bromosuccinimide; tetrakis(triphenylphosphine) palladium⁽⁰⁾; sodium carbonate; silver(l) oxide; lithium diisopropyl amide; dibenzoyl peroxide; In tetrahydrofuran; tetrachloromethane; ethanol; dichloromethane; toluene; 2.1: Suzuki coupling;
DOI:10.1016/j.bmcl.2004.07.004