(3RS,6R)-6-(2,3-dimethoxy-4-methylphenyl)-1-trimethylsilylhept-1-yn-3-ol

Base Information

Chemical Name:(3RS,6R)-6-(2,3-dimethoxy-4-methylphenyl)-1-trimethylsilylhept-1-yn-3-ol
CAS No.:406672-93-3
Molecular Formula:C₁₉H₃₀O₃Si
Molecular Weight:334.531
Hs Code.:

Synonyms:(3RS,6R)-6-(2,3-dimethoxy-4-methylphenyl)-1-trimethylsilylhept-1-yn-3-ol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of (3RS,6R)-6-(2,3-dimethoxy-4-methylphenyl)-1-trimethylsilylhept-1-yn-3-ol

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Technology Process of (3RS,6R)-6-(2,3-dimethoxy-4-methylphenyl)-1-trimethylsilylhept-1-yn-3-ol

There total 6 articles about (3RS,6R)-6-(2,3-dimethoxy-4-methylphenyl)-1-trimethylsilylhept-1-yn-3-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 406672-92-2
(R)-4-(2,3-dimethoxy-4-methylphenyl)pentanal

: 1066-54-2
trimethylsilylacetylene

: 406672-93-3
(3RS,6R)-6-(2,3-dimethoxy-4-methylphenyl)-1-trimethylsilylhept-1-yn-3-ol

Guidance literature:: trimethylsilylacetylene; With ethylmagnesium bromide; In tetrahydrofuran; at 0 - 20 ℃; for 1h;

(R)-4-(2,3-dimethoxy-4-methylphenyl)pentanal; In tetrahydrofuran; at 0 ℃; for 0.333333h;
DOI:10.1039/b102960f

Reference yield:

: 4463-33-6
1,2-dimethoxy-3-methylbenzene

: 406672-93-3
(3RS,6R)-6-(2,3-dimethoxy-4-methylphenyl)-1-trimethylsilylhept-1-yn-3-ol

Guidance literature:: Multi-step reaction with 4 steps

1.1: TMEDA; t-BuLi / hexane; pentane / 8 h / 20 °C

1.2: 75 percent / ICH₂CH₂I / 2 h / 0 - 20 °C

2.1: 85 percent / DIBAL-H / diethyl ether / 0.5 h / -78 °C

3.1: EtMgBr / tetrahydrofuran / 1 h / 0 - 20 °C

3.2: 90 percent / tetrahydrofuran / 0.33 h / 0 °C

With N,N,N,N,-tetramethylethylenediamine; ethylmagnesium bromide; tert.-butyl lithium; diisobutylaluminium hydride; In tetrahydrofuran; diethyl ether; hexane; pentane;
DOI:10.1039/b102960f

Reference yield:

: 132341-85-6
(+)-(2E)-(4S)-ethyl 4-hydroxy-2-pentenoate

: 406672-93-3
(3RS,6R)-6-(2,3-dimethoxy-4-methylphenyl)-1-trimethylsilylhept-1-yn-3-ol

Guidance literature:: Multi-step reaction with 4 steps

1.1: 96 percent / Et₃N; DMAP / CH₂Cl₂ / 5 h / 20 °C

2.1: 85 percent / DIBAL-H / diethyl ether / 0.5 h / -78 °C

3.1: EtMgBr / tetrahydrofuran / 1 h / 0 - 20 °C

3.2: 90 percent / tetrahydrofuran / 0.33 h / 0 °C

With dmap; ethylmagnesium bromide; diisobutylaluminium hydride; triethylamine; In tetrahydrofuran; diethyl ether; dichloromethane;
DOI:10.1039/b102960f