2-(2,4-difluorophenyl)-1-((3-fluorobenzyl)(prop-2-ynyl)amino)-3-(1H-1,2,4-triazol-1-yl)propan-2-ol

Base Information

Chemical Name:2-(2,4-difluorophenyl)-1-((3-fluorobenzyl)(prop-2-ynyl)amino)-3-(1H-1,2,4-triazol-1-yl)propan-2-ol
CAS No.:1236156-40-3
Molecular Formula:C₂₁H₁₉F₃N₄O
Molecular Weight:400.403
Hs Code.:

Synonyms:2-(2,4-difluorophenyl)-1-((3-fluorobenzyl)(prop-2-ynyl)amino)-3-(1H-1,2,4-triazol-1-yl)propan-2-ol

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Chemical Property of 2-(2,4-difluorophenyl)-1-((3-fluorobenzyl)(prop-2-ynyl)amino)-3-(1H-1,2,4-triazol-1-yl)propan-2-ol

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Technology Process of 2-(2,4-difluorophenyl)-1-((3-fluorobenzyl)(prop-2-ynyl)amino)-3-(1H-1,2,4-triazol-1-yl)propan-2-ol

There total 2 articles about 2-(2,4-difluorophenyl)-1-((3-fluorobenzyl)(prop-2-ynyl)amino)-3-(1H-1,2,4-triazol-1-yl)propan-2-ol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1262683-31-7
C₁₄H₁₄F₂N₄O*ClH

: 456-42-8
m-fluorobenzyl chloride

: 1236156-40-3
2-(2,4-difluorophenyl)-1-((3-fluorobenzyl)(prop-2-ynyl)amino)-3-(1H-1,2,4-triazol-1-yl)propan-2-ol

Guidance literature:: With potassium carbonate; potassium iodide; In acetonitrile; Reflux;
DOI:10.1016/j.cclet.2013.01.015

Reference yield:

: 86386-77-8
1-[2-(2,4-difluorophenyl)-2,3-epoxypropyl]-1H-1,2,4-triazole methanesulfonate

: 1236156-40-3
2-(2,4-difluorophenyl)-1-((3-fluorobenzyl)(prop-2-ynyl)amino)-3-(1H-1,2,4-triazol-1-yl)propan-2-ol

Guidance literature:: Multi-step reaction with 2 steps

1: triethylamine / ethanol / Reflux

2: potassium iodide; potassium carbonate / acetonitrile / Reflux

With potassium carbonate; triethylamine; potassium iodide; In ethanol; acetonitrile;
DOI:10.1016/j.cclet.2013.01.015