1-{1-[2-(3,4-Bis-benzyloxy-phenyl)-2-hydroxy-ethyl]-piperidin-4-yl}-1,3-dihydro-benzoimidazol-2-one; hydrochloride

Base Information

• Chemical Name: 1-{1-[2-(3,4-Bis-benzyloxy-phenyl)-2-hydroxy-ethyl]-piperidin-4-yl}-1,3-dihydro-benzoimidazol-2-one; hydrochloride
• CAS No.: 82832-84-6
• Molecular Formula: C₃₄H₃₅N₃O₄*ClH
• Molecular Weight: 586.131

Synonyms:1-{1-[2-(3,4-Bis-benzyloxy-phenyl)-2-hydroxy-ethyl]-piperidin-4-yl}-1,3-dihydro-benzoimidazol-2-one; hydrochloride

Chemical Property of 1-{1-[2-(3,4-Bis-benzyloxy-phenyl)-2-hydroxy-ethyl]-piperidin-4-yl}-1,3-dihydro-benzoimidazol-2-one; hydrochloride

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Technology Process of 1-{1-[2-(3,4-Bis-benzyloxy-phenyl)-2-hydroxy-ethyl]-piperidin-4-yl}-1,3-dihydro-benzoimidazol-2-one; hydrochloride

There total 3 articles about 1-{1-[2-(3,4-Bis-benzyloxy-phenyl)-2-hydroxy-ethyl]-piperidin-4-yl}-1,3-dihydro-benzoimidazol-2-one; hydrochloride which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 57.9%

1-{1-[2-(3,4-Bis-benzyloxy-phenyl)-2-oxo-ethyl]-piperidin-4-yl}-1,3-dihydro-benzoimidazol-2-one (82832-79-9) → 1-{1-[2-(3,4-Bis-benzyloxy-phenyl)-2-hydroxy-ethyl]-piperidin-4-yl}-1,3-dihydro-benzoimidazol-2-one; hydrochloride (82832-84-6)

Guidance literature:

With hydrogenchloride; sodium tetrahydroborate; In methanol; for 1h; Ambient temperature;

DOI:10.1248/cpb.30.462

Reference yield:

2-bromo-3',4'-bis(benzyloxy)acetophenone (27628-05-3) → 1-{1-[2-(3,4-Bis-benzyloxy-phenyl)-2-hydroxy-ethyl]-piperidin-4-yl}-1,3-dihydro-benzoimidazol-2-one; hydrochloride (82832-84-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 92.5 percent / Et₃N / methanol / 6 h / Ambient temperature

2: 57.9 percent / NaBH₄,HCl / methanol / 1 h / Ambient temperature

With hydrogenchloride; sodium tetrahydroborate; triethylamine; In methanol;

DOI:10.1248/cpb.30.462

Reference yield:

4-(2-keto-1-benzimidazolinyl)piperidine (20662-53-7) → 1-{1-[2-(3,4-Bis-benzyloxy-phenyl)-2-hydroxy-ethyl]-piperidin-4-yl}-1,3-dihydro-benzoimidazol-2-one; hydrochloride (82832-84-6)

Guidance literature:

Multi-step reaction with 2 steps

1: 92.5 percent / Et₃N / methanol / 6 h / Ambient temperature

2: 57.9 percent / NaBH₄,HCl / methanol / 1 h / Ambient temperature

With hydrogenchloride; sodium tetrahydroborate; triethylamine; In methanol;

DOI:10.1248/cpb.30.462

upstream raw materials:

1-{1-[2-(3,4-Bis-benzyloxy-phenyl)-2-oxo-ethyl]-piperidin-4-yl}-1,3-dihydro-benzoimidazol-2-one

2-bromo-3',4'-bis(benzyloxy)acetophenone

4-(2-keto-1-benzimidazolinyl)piperidine

Downstream raw materials:

1-<2-hydroxy-2-(3,4-dihydroxyphenyl)ethyl>-4-(1,3-dihydro-2H-benzimidazol-2-one-1-yl)piperidine hydrochloride

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