(3-(((2R,5R)-5-(((5-fluoropyridin-2-yl)oxy)methy)-2-methyl-piperidin-1-yl)carbonyl)-4-pyrimidin-2-yl-phenyl)-methanol

Base Information

Chemical Name:(3-(((2R,5R)-5-(((5-fluoropyridin-2-yl)oxy)methy)-2-methyl-piperidin-1-yl)carbonyl)-4-pyrimidin-2-yl-phenyl)-methanol
CAS No.:1088991-77-8
Molecular Formula:C₂₄H₂₅FN₄O₃
Molecular Weight:436.486
Hs Code.:

Synonyms:(3-(((2R,5R)-5-(((5-fluoropyridin-2-yl)oxy)methy)-2-methyl-piperidin-1-yl)carbonyl)-4-pyrimidin-2-yl-phenyl)-methanol

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Chemical Property of (3-(((2R,5R)-5-(((5-fluoropyridin-2-yl)oxy)methy)-2-methyl-piperidin-1-yl)carbonyl)-4-pyrimidin-2-yl-phenyl)-methanol

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Technology Process of (3-(((2R,5R)-5-(((5-fluoropyridin-2-yl)oxy)methy)-2-methyl-piperidin-1-yl)carbonyl)-4-pyrimidin-2-yl-phenyl)-methanol

There total 18 articles about (3-(((2R,5R)-5-(((5-fluoropyridin-2-yl)oxy)methy)-2-methyl-piperidin-1-yl)carbonyl)-4-pyrimidin-2-yl-phenyl)-methanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 1088994-45-9
3-(((2R,5R)-5-(((5-fluoropyridin-2-yl)oxy)methyl)-2-methylpiperidin-1-yl)carbonyl)-4-pyrimidin-2-yl-benzyl acetate

: 1088991-77-8
(3-(((2R,5R)-5-(((5-fluoropyridin-2-yl)oxy)methy)-2-methyl-piperidin-1-yl)carbonyl)-4-pyrimidin-2-yl-phenyl)-methanol

Guidance literature:: With methanol; sodium hydroxide; water; In tetrahydrofuran; at 20 ℃; for 3h;

Reference yield:

: 25252-00-0
2-bromo-5-iodobenzoic acid

: 1088991-77-8
(3-(((2R,5R)-5-(((5-fluoropyridin-2-yl)oxy)methy)-2-methyl-piperidin-1-yl)carbonyl)-4-pyrimidin-2-yl-phenyl)-methanol

Guidance literature:: Multi-step reaction with 7 steps

1: benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine / N,N-dimethyl-formamide / 18 h / 22 °C

2: potassium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / N,N-dimethyl-formamide / 77 h / 20 - 85 °C

3: sodium periodate; osmium(VIII) oxide / tetrahydrofuran; water; tert-butyl alcohol / 4 h / 20 °C

4: lithium borohydride / tetrahydrofuran / 0.5 h / 20 °C

5: pyridine; dmap / 0.5 h / 20 °C

6: copper(l) iodide; cesium fluoride / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 0.42 h / 150 °C / Microwave irradiation

7: methanol; sodium hydroxide; water / tetrahydrofuran / 3 h / 20 °C

With pyridine; methanol; dmap; sodium hydroxide; sodium periodate; copper(l) iodide; osmium(VIII) oxide; lithium borohydride; water; potassium carbonate; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; cesium fluoride; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; In tetrahydrofuran; water; N,N-dimethyl-formamide; tert-butyl alcohol;

Reference yield:

: 278789-37-0
(6-methyl-piperidin-3-yl)methanol

: 1088991-77-8
(3-(((2R,5R)-5-(((5-fluoropyridin-2-yl)oxy)methy)-2-methyl-piperidin-1-yl)carbonyl)-4-pyrimidin-2-yl-phenyl)-methanol

Guidance literature:: Multi-step reaction with 11 steps

1: triethylamine / dichloromethane / 22 °C

2: ethanol; hexane / Resolution of racemate

3: PS-triphenylphosphine; di-isopropyl azodicarboxylate / dichloromethane

4: hydrogen / 10 % Pd(OH)2/C / ethanol / 0.67 h / 22 °C / 760.05 Torr

5: benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine / N,N-dimethyl-formamide / 18 h / 22 °C

6: potassium carbonate / (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride / N,N-dimethyl-formamide / 77 h / 20 - 85 °C

7: sodium periodate; osmium(VIII) oxide / tetrahydrofuran; water; tert-butyl alcohol / 4 h / 20 °C

8: lithium borohydride / tetrahydrofuran / 0.5 h / 20 °C

9: pyridine; dmap / 0.5 h / 20 °C

10: copper(l) iodide; cesium fluoride / tetrakis(triphenylphosphine) palladium⁽⁰⁾ / N,N-dimethyl-formamide / 0.42 h / 150 °C / Microwave irradiation

11: methanol; sodium hydroxide; water / tetrahydrofuran / 3 h / 20 °C

With pyridine; methanol; dmap; sodium hydroxide; sodium periodate; copper(l) iodide; osmium(VIII) oxide; lithium borohydride; PS-triphenylphosphine; di-isopropyl azodicarboxylate; water; hydrogen; potassium carbonate; benzotriazol-1-ol; N-(3-dimethylaminopropyl)-N-ethylcarbodiimide; triethylamine; cesium fluoride; (1,1'-bis(diphenylphosphino)ferrocene)palladium(II) dichloride; tetrakis(triphenylphosphine) palladium⁽⁰⁾; 10 % Pd(OH)2/C; In tetrahydrofuran; ethanol; hexane; dichloromethane; water; N,N-dimethyl-formamide; tert-butyl alcohol;