4-[4-(2,4-dioxothiazolidin-5-ylidenemethyl)-2-methoxyphenoxy]-3-trifluoromethylbenzonitrile

Base Information

• Chemical Name: 4-[4-(2,4-dioxothiazolidin-5-ylidenemethyl)-2-methoxyphenoxy]-3-trifluoromethylbenzonitrile
• CAS No.: 1055361-35-7
• Molecular Formula: C₁₉H₁₁F₃N₂O₄S
• Molecular Weight: 420.369

Synonyms:4-[4-(2,4-dioxothiazolidin-5-ylidenemethyl)-2-methoxyphenoxy]-3-trifluoromethylbenzonitrile

Chemical Property of 4-[4-(2,4-dioxothiazolidin-5-ylidenemethyl)-2-methoxyphenoxy]-3-trifluoromethylbenzonitrile

Chemical Property:

Purity/Quality:

97% ^*data from raw suppliers

4-(4-((2,4-Dioxothiazolidin-5-ylidene)methyl)-2-methoxyphenoxy)-3-(trifluoromethyl)benzonitrile 95+% ^*data from reagent suppliers

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Technology Process of 4-[4-(2,4-dioxothiazolidin-5-ylidenemethyl)-2-methoxyphenoxy]-3-trifluoromethylbenzonitrile

There total 2 articles about 4-[4-(2,4-dioxothiazolidin-5-ylidenemethyl)-2-methoxyphenoxy]-3-trifluoromethylbenzonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 84.0%

thiazoline-2,4-dione (2295-31-0) + 4-(4-formyl-2-methoxyphenoxy)-3-trifluoromethylbenzonitrile (1055361-66-4) → 4-[4-(2,4-dioxothiazolidin-5-ylidenemethyl)-2-methoxyphenoxy]-3-trifluoromethylbenzonitrile (1055361-35-7)

Guidance literature:

With piperidine; benzoic acid; In toluene; at 130 ℃; for 12h;

DOI:10.1021/jm101063h

Reference yield:

4-Fluoro-3-(trifluoromethyl)benzonitrile (67515-59-7) + vanillin (121-33-5,8014-42-4) → 4-[4-(2,4-dioxothiazolidin-5-ylidenemethyl)-2-methoxyphenoxy]-3-trifluoromethylbenzonitrile (1055361-35-7)

Guidance literature:

Multi-step reaction with 2 steps

1: potassium carbonate / N,N-dimethyl-formamide / 5 h / 95 °C

2: piperidine; benzoic acid / toluene / 12 h / 130 °C

With piperidine; potassium carbonate; benzoic acid; In N,N-dimethyl-formamide; toluene; 2: Knoevenagel condensation;

DOI:10.1021/jm101063h

upstream raw materials:

thiazoline-2,4-dione

4-(4-formyl-2-methoxyphenoxy)-3-trifluoromethylbenzonitrile

4-Fluoro-3-(trifluoromethyl)benzonitrile

vanillin

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