4-Amino-7-(2-C-methyl-beta-D-ribofuranosyl)-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile

Base Information

Chemical Name:4-Amino-7-(2-C-methyl-beta-D-ribofuranosyl)-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile
CAS No.:141232-24-8
Molecular Formula:C₁₃H₁₅N₅O₄
Molecular Weight:305.293
Hs Code.:
Mol file:141232-24-8.mol

Synonyms:4-Amino-7-(2-C-methyl-beta-D-ribofuranosyl)-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile

Suppliers and Price of 4-Amino-7-(2-C-methyl-beta-D-ribofuranosyl)-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

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Chemicals and raw materials
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Total 5 raw suppliers

Chemical Property of 4-Amino-7-(2-C-methyl-beta-D-ribofuranosyl)-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile

Chemical Property:

Boiling Point:690.1±55.0 °C(Predicted)
PKA:12.37±0.70(Predicted)
Density:1.76±0.1 g/cm3(Predicted)

Purity/Quality:: 97% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:: SDS file from LookChem

Useful:

Technology Process of 4-Amino-7-(2-C-methyl-beta-D-ribofuranosyl)-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile

There total 9 articles about 4-Amino-7-(2-C-methyl-beta-D-ribofuranosyl)-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 90.0%

: 557-21-1
zinc(II) cyanide

: 847551-49-9
5-iodo-7-(2-C-methyl-β-D-ribofuranosyl)-7H-pyrrolo[2,3-d]pyrimidin-4-amine

: 141232-24-8
4-amino-7-(2-C-methyl-β-D-ribofuranosyl)-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile

Guidance literature:: With tetrakis(triphenylphosphine) palladium⁽⁰⁾; In N,N-dimethyl-formamide; at 150 ℃; for 0.25h; Microwave irradiation;
DOI:10.1016/j.bmc.2012.05.067

Reference yield: 70.0%

: 729595-78-2
(2R,3R,4R,5R)-2-(4-amino-5-cyano-7H-pyrrolo[2,3-d]pyrimidin-7-yl)-5-(benzoyloxymethyl)-3-methyltetrahydrofuran-3,4-diyl dibenzoate

: 141232-24-8
4-amino-7-(2-C-methyl-β-D-ribofuranosyl)-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile

Guidance literature:: With ammonia; In methanol; at 20 ℃; for 16h;

Reference yield:

: 19393-83-0
4-amino-6-bromo-5-cyanopyrrolo[2,3-d]pyrimidine

: 141232-24-8
4-amino-7-(2-C-methyl-β-D-ribofuranosyl)-7H-pyrrolo[2,3-d]pyrimidine-5-carbonitrile

Guidance literature:: Multi-step reaction with 3 steps

1: 84 percent / N,N-dimethylaminopyridine (DMAP), pyridine / 36 h / 90 °C

2: 76 percent / conc. NH₄OH, H₂ / 10percent Pd/C / ethanol / 27 h / 25 °C / 760 Torr

3: 1.) NaH, molecular sieves 4A, 3.) TFA

With pyridine; dmap; ammonium hydroxide; 4 A molecular sieve; hydrogen; sodium hydride; trifluoroacetic acid; palladium on activated charcoal; In ethanol;