Acetic acid (1S,3aS,3bR,5aS,10aS,10bS,12aS)-8-(4-methoxy-benzoyl)-10a,12a-dimethyl-2,3,3a,3b,4,5,5a,6,10,10a,10b,11,12,12a-tetradecahydro-1H-7-oxa-dicyclopenta[a,h]phenanthren-1-yl ester

Base Information

• Chemical Name: Acetic acid (1S,3aS,3bR,5aS,10aS,10bS,12aS)-8-(4-methoxy-benzoyl)-10a,12a-dimethyl-2,3,3a,3b,4,5,5a,6,10,10a,10b,11,12,12a-tetradecahydro-1H-7-oxa-dicyclopenta[a,h]phenanthren-1-yl ester
• CAS No.: 1059550-27-4
• Molecular Formula: C₃₁H₃₈O₅
• Molecular Weight: 490.64
• Mol file: 1059550-27-4.mol

Synonyms:Acetic acid (1S,3aS,3bR,5aS,10aS,10bS,12aS)-8-(4-methoxy-benzoyl)-10a,12a-dimethyl-2,3,3a,3b,4,5,5a,6,10,10a,10b,11,12,12a-tetradecahydro-1H-7-oxa-dicyclopenta[a,h]phenanthren-1-yl ester

Chemical Property of Acetic acid (1S,3aS,3bR,5aS,10aS,10bS,12aS)-8-(4-methoxy-benzoyl)-10a,12a-dimethyl-2,3,3a,3b,4,5,5a,6,10,10a,10b,11,12,12a-tetradecahydro-1H-7-oxa-dicyclopenta[a,h]phenanthren-1-yl ester

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of Acetic acid (1S,3aS,3bR,5aS,10aS,10bS,12aS)-8-(4-methoxy-benzoyl)-10a,12a-dimethyl-2,3,3a,3b,4,5,5a,6,10,10a,10b,11,12,12a-tetradecahydro-1H-7-oxa-dicyclopenta[a,h]phenanthren-1-yl ester

There total 2 articles about Acetic acid (1S,3aS,3bR,5aS,10aS,10bS,12aS)-8-(4-methoxy-benzoyl)-10a,12a-dimethyl-2,3,3a,3b,4,5,5a,6,10,10a,10b,11,12,12a-tetradecahydro-1H-7-oxa-dicyclopenta[a,h]phenanthren-1-yl ester which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

4-methoxy-benzoyl chloride (100-07-2) + Acetic acid (1S,3aS,3bR,5aS,10aS,10bS,12aS)-10a,12a-dimethyl-2,3,3a,3b,4,5,5a,6,10,10a,10b,11,12,12a-tetradecahydro-1H-7-oxa-dicyclopenta[a,h]phenanthren-1-yl ester (160458-67-3) → Acetic acid (1S,3aS,3bR,5aS,10aS,10bS,12aS)-8-(4-methoxy-benzoyl)-10a,12a-dimethyl-2,3,3a,3b,4,5,5a,6,10,10a,10b,11,12,12a-tetradecahydro-1H-7-oxa-dicyclopenta[a,h]phenanthren-1-yl ester (1059550-27-4)

Guidance literature:

With diethylaluminium chloride; In hexane; dichloromethane; at -20 ℃; for 2h;

DOI:10.1021/jm00050a019

Reference yield:

(5α,17β)-Androst-2-eno<3,2-b>furan-17-ol (135643-79-7) → Acetic acid (1S,3aS,3bR,5aS,10aS,10bS,12aS)-8-(4-methoxy-benzoyl)-10a,12a-dimethyl-2,3,3a,3b,4,5,5a,6,10,10a,10b,11,12,12a-tetradecahydro-1H-7-oxa-dicyclopenta[a,h]phenanthren-1-yl ester (1059550-27-4)

Guidance literature:

Multi-step reaction with 2 steps

1: pyridine, 4-(dimethylamino)pyridine / 24 h / Ambient temperature

2: diethyl aluminum chloride / CH₂Cl₂; hexane / 2 h / -20 °C

With pyridine; dmap; diethylaluminium chloride; In hexane; dichloromethane;

DOI:10.1021/jm00050a019

Reference yield:

Acetic acid (1S,3aS,3bR,5aS,10aS,10bS,12aS)-8-(4-methoxy-benzoyl)-10a,12a-dimethyl-2,3,3a,3b,4,5,5a,6,10,10a,10b,11,12,12a-tetradecahydro-1H-7-oxa-dicyclopenta[a,h]phenanthren-1-yl ester (1059550-27-4) → (5alpha,17beta-17-Hydroxyandrosta-2,4-dieno[3,2-b]-furan-5'-yl)(4-methoxyphenyl) methanone

Guidance literature:

With potassium carbonate; In tetrahydrofuran; methanol; for 20h; Yield given; Ambient temperature;

DOI:10.1021/jm00050a019

upstream raw materials:

4-methoxy-benzoyl chloride

Acetic acid (1S,3aS,3bR,5aS,10aS,10bS,12aS)-10a,12a-dimethyl-2,3,3a,3b,4,5,5a,6,10,10a,10b,11,12,12a-tetradecahydro-1H-7-oxa-dicyclopenta[a,h]phenanthren-1-yl ester

(5α,17β)-Androst-2-eno<3,2-b>furan-17-ol