2-(2-methoxy-4-nitrophenylsulfonylamino)ethyl methanesulfonate

Base Information

• Chemical Name: 2-(2-methoxy-4-nitrophenylsulfonylamino)ethyl methanesulfonate
• CAS No.: 1370451-31-2
• Molecular Formula: C₁₀H₁₄N₂O₈S₂
• Molecular Weight: 354.362
• Mol file: 1370451-31-2.mol

Synonyms:2-(2-methoxy-4-nitrophenylsulfonylamino)ethyl methanesulfonate

Chemical Property of 2-(2-methoxy-4-nitrophenylsulfonylamino)ethyl methanesulfonate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2-(2-methoxy-4-nitrophenylsulfonylamino)ethyl methanesulfonate

There total 1 articles about 2-(2-methoxy-4-nitrophenylsulfonylamino)ethyl methanesulfonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 66.0%

2-(2-methoxy-4-nitrophenylsulfonylamino)ethanol (86919-14-4) + methanesulfonyl chloride (124-63-0) → 2-(2-methoxy-4-nitrophenylsulfonylamino)ethyl methanesulfonate (1370451-31-2)

Guidance literature:

With triethylamine; In dichloromethane; at 0 - 20 ℃; Inert atmosphere;

DOI:10.1016/j.bmcl.2012.02.071

Reference yield:

2-(2-methoxy-4-nitrophenylsulfonylamino)ethyl methanesulfonate (1370451-31-2) → C9H10N2O5S (1370451-46-9)

Guidance literature:

With potassium hydroxide; In water; toluene; at 20 ℃; for 0.5h;

DOI:10.1016/j.bmcl.2012.02.071

Reference yield:

2-(2-methoxy-4-nitrophenylsulfonylamino)ethyl methanesulfonate (1370451-31-2) → 1-[2-(2-methoxy-4-nitrophenylsulfonylamino)ethyl]-4,7,10-tris(carboxymethyl)-1,4,7,10-tetraazacyclododecane (1370451-37-8)

Guidance literature:

Multi-step reaction with 2 steps

1.1: potassium hydroxide / water; toluene / 0.5 h / 20 °C

2.1: sodium carbonate / acetonitrile / 5 h / Inert atmosphere; Reflux

2.2: 3 h / 20 °C

With sodium carbonate; potassium hydroxide; In water; toluene; acetonitrile;

DOI:10.1016/j.bmcl.2012.02.071

upstream raw materials:

2-(2-methoxy-4-nitrophenylsulfonylamino)ethanol

methanesulfonyl chloride

Downstream raw materials:

1-[2-(2-methoxy-4-nitrophenylsulfonylamino)ethyl]-4,7,10-tris(carboxymethyl)-1,4,7,10-tetraazacyclododecane

1-[2-(4-amino-2-methoxyphenylsulfonylamino)ethyl]-4,7,10-tris(carboxymethyl)-1,4,7,10-tetraazacyclododecane

C₉H₁₀N₂O₅S