(2R,3S)-2-Amino-3-hydroxy-3-(2-fluorophenyl)propanoic acid

Base Information

Chemical Name:(2R,3S)-2-Amino-3-hydroxy-3-(2-fluorophenyl)propanoic acid
CAS No.:136030-51-8
Molecular Formula:C₉H₁₀FNO₃
Molecular Weight:199.182
Hs Code.:
DSSTox Substance ID:DTXSID001280334
Nikkaji Number:J485.958H

Synonyms:DTXSID001280334;(betaS)-2-Fluoro-beta-hydroxy-D-phenylalanine;(2R,3S)-2-Amino-3-hydroxy-3-(2-fluorophenyl)propanoic acid;136030-51-8

Suppliers and Price of (2R,3S)-2-Amino-3-hydroxy-3-(2-fluorophenyl)propanoic acid

Supply Marketing:

Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

Manufacturers and distributors:

Manufacture/Brand
Chemicals and raw materials
Packaging
price

Total 2 raw suppliers

Chemical Property of (2R,3S)-2-Amino-3-hydroxy-3-(2-fluorophenyl)propanoic acid

Chemical Property:

XLogP3:-2.6
Hydrogen Bond Donor Count:3
Hydrogen Bond Acceptor Count:5
Rotatable Bond Count:3
Exact Mass:199.06447134
Heavy Atom Count:14
Complexity:212

Purity/Quality:: 95% ^*data from raw suppliers

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1=CC=C(C(=C1)C(C(C(=O)O)N)O)F
Isomeric SMILES:C1=CC=C(C(=C1)[C@@H]([C@H](C(=O)O)N)O)F

Technology Process of (2R,3S)-2-Amino-3-hydroxy-3-(2-fluorophenyl)propanoic acid

There total 5 articles about (2R,3S)-2-Amino-3-hydroxy-3-(2-fluorophenyl)propanoic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 1111092-20-6
(1R,2S,5R,8S,1'S)-5-(1'-hydroxy-o-fluorobenzyl)-1,11,11-trimethyl-3-oxa-6-azatricyclo[6.2.1.0(2,7)]undec-6-en-4-one

: 23963-16-8
(1S,3S,4R)-3-hydroxy-4,7,7-trimethylbicyclo[2.2.1]heptan-2-one

: 136030-51-8
(2R,3S)-2-amino-3-hydroxy-3-(o-fluorophenyl)propanoic acid

Guidance literature:: With hydrogenchloride; water; at 80 ℃; for 3h; optical yield given as %ee;
DOI:10.1021/jo8023973

Reference yield:

: C₉H₈FN₃O₃

: 136030-51-8
(2R,3S)-2-amino-3-hydroxy-3-(o-fluorophenyl)propanoic acid

Guidance literature:: With palladium 10% on activated carbon; hydrogen; In ethyl acetate; at 20 ℃; for 5h; under 760.051 Torr;
DOI:10.1002/anie.201501607

Reference yield:

: 446-52-6
2-Fluorobenzaldehyde

: 56-40-6,18875-39-3,25718-94-9
glycine

: 136030-51-8
(2R,3S)-2-amino-3-hydroxy-3-(o-fluorophenyl)propanoic acid

Guidance literature:: With hydrogenchloride; (S)-BAB; nickel(II); sodium methylate; Product distribution; various aldehydes, enantioselectivity;