dipropyl 2-(1-(4-chlorophenyl)-3-(4-fluorophenyl)-3-oxopropyl)malonate

Base Information

• Chemical Name: dipropyl 2-(1-(4-chlorophenyl)-3-(4-fluorophenyl)-3-oxopropyl)malonate
• CAS No.: 1012919-05-9
• Molecular Formula: C₂₄H₂₆ClFO₅
• Molecular Weight: 448.919
• Mol file: 1012919-05-9.mol

Synonyms:dipropyl 2-(1-(4-chlorophenyl)-3-(4-fluorophenyl)-3-oxopropyl)malonate

Chemical Property of dipropyl 2-(1-(4-chlorophenyl)-3-(4-fluorophenyl)-3-oxopropyl)malonate

Chemical Property:

Purity/Quality:

Safty Information:

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Technology Process of dipropyl 2-(1-(4-chlorophenyl)-3-(4-fluorophenyl)-3-oxopropyl)malonate

There total 2 articles about dipropyl 2-(1-(4-chlorophenyl)-3-(4-fluorophenyl)-3-oxopropyl)malonate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 97.0%

dipropyl malonate (1117-19-7) + (E)-3-(4-chlorophenyl)-1-(4-fluorophenyl)prop-2-en-1-one (22966-32-1) → dipropyl 2-(1-(4-chlorophenyl)-3-(4-fluorophenyl)-3-oxopropyl)malonate (1012919-05-9)

Guidance literature:

With 4 A molecular sieve; Sr(O-i-Pr)2; (1R,2R)-1,2-diphenylethane-1,2-bis(2,5-Me₂C₆H₃)sulfonamide; In toluene; at 25 ℃; for 7h;

DOI:10.1021/ja710332h

Reference yield: 97.0%

→ dipropyl 2-(1-(4-chlorophenyl)-3-(4-fluorophenyl)-3-oxopropyl)malonate (1012919-05-9)

Guidance literature:

upstream raw materials:

dipropyl malonate

(E)-3-(4-chlorophenyl)-1-(4-fluorophenyl)prop-2-en-1-one