22966-32-1

Usage

Uses

Used in Organic Synthesis:
(E)-3-(4-chlorophenyl)-1-(4-fluorophenyl)prop-2-en-1-one is used as a key intermediate in organic synthesis for the creation of complex molecular structures. Its unique combination of functional groups allows for a wide range of reactions, making it a versatile building block in the synthesis of various organic compounds.
Used in Pharmaceutical Research:
In the pharmaceutical industry, (E)-3-(4-chlorophenyl)-1-(4-fluorophenyl)prop-2-en-1-one is utilized as a starting material or a structural component in the development of new drug candidates. Its chemical properties and reactivity make it a promising candidate for the design and synthesis of novel therapeutic agents.
Used in Materials Science:
(E)-3-(4-chlorophenyl)-1-(4-fluorophenyl)prop-2-en-1-one may also find applications in the field of materials science. Its structural features could be exploited to develop new materials with specific properties, such as improved stability, reactivity, or selectivity in various chemical processes.
Used in Industrial Chemistry:
(E)-3-(4-chlorophenyl)-1-(4-fluorophenyl)prop-2-en-1-one's potential applications extend to industrial chemistry, where it could be employed as a catalyst or a reactant in large-scale chemical production processes. Its unique structure and reactivity make it a candidate for optimizing and enhancing the efficiency of industrial chemical reactions.

Upstream product

• 766-98-3 1-ethynyl-4-fluorobenzene 
• 104-88-1 4-chlorobenzaldehyde 
• 403-42-9 1-(4-fluorophenyl)ethanone 

Downstream Products

• 1173789-81-5 1-(p-fluorophenyl)-3-(p-chlorophenyl)prop-2-en-1-one 3-methylquinoxalin-2-yl hydrazone 
• 1242261-28-4 5-(4-chlorophenyl)-1-(5-deoxy-1,2-O-isopropylidene-α-Dxylofuranos-5-yl)-4-(4-fluorobenzoyl)-1H-1,2,3-triazole 
• 1050196-71-8 (E)-3-(4-chlorophenyl)-1-(4-morpholin-4-ylphenyl)prop-2-en-1-one 
• 1260214-47-8 (E)-3-(4-chlorophenyl)-1-(4-(4-methylpiperazin-1-yl)phenyl)prop-2-en-1-one 
• 1260214-48-9 (E)-3-(4-chlorophenyl)-1-(4-(furan-2-ylmethylamino)phenyl)prop-2-en-1-one 
• 1260214-46-7 (E)-3-(4-chlorophenyl)-1-(4-(3-(dimethylamino)propylamino)phenyl)prop-2-en-1-one 
• 1012919-05-9 dipropyl 2-(1-(4-chlorophenyl)-3-(4-fluorophenyl)-3-oxopropyl)malonate 
• 1033804-52-2 C₂₂H₁₄ClF₂N₃S 

Relevant academic research and scientific papers

Molecular structure, FT-IR, first order hyperpolarizability, NBO analysis, HOMO and LUMO, MEP analysis of (E)-3-(4-chlorophenyl)-1-(4-fluorophenyl)prop-2- en-1-one by HF and density functional methods

(E)-3-(4-Chlorophenyl)-1-(4-fluorophenyl)prop-2-en-1-one is synthesized by reacting 4-fluoroacetophenone and 4-chlorobenzaldehyde in ethanol in the presence of sodium hydroxide. The structure of the compound was confirmed by IR and single crystal X-ray di

TRPV3 inhibitor and preparation method thereof

The invention discloses a TRPV3 inhibitor which is formed by sequentially connecting an R1 group, an R group and an R2 group, and the molecular structural general formula of the TRPV3 inhibitor is shown as a formula 1 in the description. The invention als

The design and synthesis of transient receptor potential vanilloid 3 inhibitors with novel skeleton

Transient receptor potential vanilloid 3 (TRPV3) channel as a member of thermo TRPV subfamily is primarily expressed in the keratinocytes of the skin and sensory neurons, and plays critical roles in various physiological and pathological processes such as

COMPOSITION FOR PROTECTING KIDNEY CONTAINING CHALCONE DERIVATIVES

The present invention relates to a composition for protecting a kidney or a composition for alleviating kidney diseases which contains a chalcone derivative. When the compound according to the present invention is used, the kidney can be protected from nephrotoxicity due to drugs and the like. Therefore, by utilizing the present specification, it is possible to make a great contribution to fields of patient treatment and welfare.COPYRIGHT KIPO 2019

Design, synthesis, biological evaluation, and molecular docking of chalcone derivatives as anti-inflammatory agents

In this study, two series of 35 new chalcone derivatives containing aryl-piperazine or aryl-sulfonyl-piperazine fragment were synthesized and their structures were characterized by1H,13C and ESI-MS. The in vivo and in vitro anti-inflammatory activities of target compounds were evaluated by using classical para-xylene-induced mice ear-swelling model and ELISA assays. Furthermore, docking studies were performed in COX-2 (4PH9). The in vivo anti-inflammatory assays indicated that most of the target compounds showed significant anti-inflammatory activities. Docking results revealed that the anti-inflammatory activities of compounds correlated with their docking results. Especially, compound 6o exhibited the most potent anti-inflammatory activity in vivo with the lowest docking score of ?17.4?kcal/mol and could significantly inhibit the release of LPS-induced IL-6 and TNF-α in a dose-dependent manner in vitro.

Phosphorous Acid Promoted Hydration-Condensation of Aromatic Alkynes with Aldehydes Affording Chalcones in an Oil/Water Two-Phase System

A simple and environmentally benign method was developed for the synthesis of chalcones in high to excellent yields by a phosphorous acid promoted alkyne-aldehyde hydration-condensation in an oil/water two-phase system. The method is the first efficient protocol for the preparation of chalcones that is mediated by a simple Bronsted acid in a two-phase system.

Mild and efficient reductive deoxygenation of epoxides to olefins with tin(II) chloride/sodium iodide as a novel reagent

A highly efficient and green protocol is reported for the reductive deoxygenation of organic epoxides to olefins using tin(II) chloride/sodium iodide as a novel reagent. The reaction gives an excellent yield (85-96%) in ethanol under reflux within 2-10 minutes, without affecting other functional groups. The advantages of our method are the use of inexpensive reagents, the eco-friendly and green reaction conditions, and the short reaction times and high yields.

Synthesis and bio-evaluation of alkylaminoaryl phenyl cyclopropyl methanones as antitubercular and antimalarial agents

A series of 4-alkylaminoaryl phenyl cyclopropyl methanones (6a-6u and 8a-8c) were synthesized from 4-fluorochalcones (3a and 3b) by cyclopropanation of double bond followed by nucleophilic substitution of F with different amines. The compounds were screened for their antitubercular and antimalarial activities against Mycobacterium tuberculosis H37Rv and Plasmodium falciparum 3D7 strains in vitro respectively. Several compounds (6a, 6d-6h, 6p, 6q and 8a-8c) exhibited good in vitro antitubercular activities with MIC values 3.12-12.5 μg/mL and preferentially inhibited the growth of P. falciparum in vitro (4a, 4c, 6a-6d, 6f, 6s, 8a and 8c) with IC50 as low as 0.080 and 0.035 μg/mL and SI values 4975 and 6948, respectively. Molecular docking studies and in vitro evaluation against FAS-II enzymes using reporter gene assays were carried out to elucidate the mode of action of these molecules. Two compounds 4a and 6g showed significant inhibition at 25 μM concentration of the compound.

Synthesis of some new 1-(6-fluorobenzothiazol-2-yl)-3-(4-fluoro- phenyl)-5-arylpyrazolines and their iodine(III) mediated oxidation to corresponding pyrazoles

The reaction of fluorinated chalcones 2 and 6-fluorobenzothiazol-2- ylhydrazine 1 in presence of catalytic amount of glacial acetic acid in refluxing ethanol yields l-(6-fluorobenzothiazol-2-yl)-3-(4-fluorophenyl)-5- arylpyrazolines 3, which undergo facile oxidation to the corresponding pyrazoles 4 in good yield using iodobenzene diacetate (IBD). The structures of the synthesized compounds have been established on the basis of their elemental analysis, MS and 1H and 13C NMR spectroscopy.

Polarographic Investigations on α,β-Unsaturated Ketones: 1-(4'-Fluorophenyl)-3-phenyl-2-propenones

The reduction of various substituted 1-(4'-fluorophenyl)-3-phenyl-2-propenones at the dropping mercury electrode has been examined.In 50percent ethanol-water buffered media fluorochalkones give two well-defined waves in acid media and three waves in neutral and alkaline media.The one-electron electroreduction in the first two steps results in the formation of dihydrochalcone, which subsequently gets further reduced to the secondary alcohol.A large variety of substituents on the benzylidene moiety of 1-(4'-fluorophenyl)-3-phenyl-2-propenone, affect the half-wave potentials according to the relation E1/2 = a + b.Substituents with a positive ? value render the reduction easier and shift the E1/2 to more positive values, whereas groups with negative ? values make the electroreduction more difficult, resulting in more negative E1/2 compared to the parent compound.A comparison of the E1/2 values of o- and p-chloro substituted 1-(4'-fluorophenyl)-3-phenyl-2-propenones shows that o-substituted derivative undergoes reduction at a more positive potential indicating a positive ortho effect for this system.