(3R,4S)-1-[(7-benzyloxymethyl-9-dezapurin-9-yl)methyl]-4-benzylthiomethyl-3-hydroxypyrrolidine

Base Information

Chemical Name:(3R,4S)-1-[(7-benzyloxymethyl-9-dezapurin-9-yl)methyl]-4-benzylthiomethyl-3-hydroxypyrrolidine
CAS No.:666831-20-5
Molecular Formula:C₃₁H₃₈N₄O₃S
Molecular Weight:546.734
Hs Code.:

Synonyms:(3R,4S)-1-[(7-benzyloxymethyl-9-dezapurin-9-yl)methyl]-4-benzylthiomethyl-3-hydroxypyrrolidine

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Chemical Property of (3R,4S)-1-[(7-benzyloxymethyl-9-dezapurin-9-yl)methyl]-4-benzylthiomethyl-3-hydroxypyrrolidine

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Technology Process of (3R,4S)-1-[(7-benzyloxymethyl-9-dezapurin-9-yl)methyl]-4-benzylthiomethyl-3-hydroxypyrrolidine

There total 4 articles about (3R,4S)-1-[(7-benzyloxymethyl-9-dezapurin-9-yl)methyl]-4-benzylthiomethyl-3-hydroxypyrrolidine which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 96.0%

: 635319-12-9
7-benzyloxymethyl-6-O-tert-butyl-9-deaza-9-formylhypoxanthine

: (3R,4S)-4-benzylthiomethyl-3-hydroxypyrrolidine hydrochloride

: 666831-20-5
(3R,4S)-1-[(7-benzyloxymethyl-9-dezapurin-9-yl)methyl]-4-benzylthiomethyl-3-hydroxypyrrolidine

Guidance literature:: With sodium cyanoborohydride; In methanol; at 20 ℃;
DOI:10.1021/jm050269z

Reference yield:

: 666831-24-9
tert-butyl (3R,4R)-3-hydroxy-4-[(methanesulfonyloxy)methyl]pyrrolidine-1-carboxylate

: 666831-20-5
(3R,4S)-1-[(7-benzyloxymethyl-9-dezapurin-9-yl)methyl]-4-benzylthiomethyl-3-hydroxypyrrolidine

Guidance literature:: Multi-step reaction with 3 steps

1.1: NaH / dimethylformamide

1.2: dimethylformamide / 1 h / 20 °C

2.1: 730 mg / aq. HCl / methanol

3.1: 96 percent / NaCNBH₃ / methanol / 20 °C

With hydrogenchloride; sodium hydride; sodium cyanoborohydride; In methanol; N,N-dimethyl-formamide;
DOI:10.1021/jm050269z

Reference yield:

: 3R,4S-4-benzylthiomethyl-1-tert-butoxycarbonyl-3-hydroxypyrrolidine

: 666831-20-5
(3R,4S)-1-[(7-benzyloxymethyl-9-dezapurin-9-yl)methyl]-4-benzylthiomethyl-3-hydroxypyrrolidine

Guidance literature:: Multi-step reaction with 2 steps

1: 730 mg / aq. HCl / methanol

2: 96 percent / NaCNBH₃ / methanol / 20 °C

With hydrogenchloride; sodium cyanoborohydride; In methanol;
DOI:10.1021/jm050269z