2',6'-dihydroxy-4'-iso-propylacetophenone

Base Information

• Chemical Name: 2',6'-dihydroxy-4'-iso-propylacetophenone
• CAS No.: 257621-55-9
• Molecular Formula: C₁₁H₁₄O₃
• Molecular Weight: 194.23
• Mol file: 257621-55-9.mol

Synonyms:2',6'-dihydroxy-4'-iso-propylacetophenone

Chemical Property of 2',6'-dihydroxy-4'-iso-propylacetophenone

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2',6'-dihydroxy-4'-iso-propylacetophenone

There total 3 articles about 2',6'-dihydroxy-4'-iso-propylacetophenone which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 77.0%

3-isopropyl-1,5-diacetoxybenzene (97025-07-5) → 2',6'-dihydroxy-4'-iso-propylacetophenone (257621-55-9)

Guidance literature:

With aluminium trichloride; In chlorobenzene; at 90 ℃; for 1h;

DOI:10.1021/jm990175n

Reference yield:

3,5-dihydroxy-1-isopropylbenzene (34993-66-3) → 2',6'-dihydroxy-4'-iso-propylacetophenone (257621-55-9)

Guidance literature:

Multi-step reaction with 2 steps

1: pyridine

2: AlCl₃ / chlorobenzene / 90 °C

With pyridine; aluminium trichloride; In chlorobenzene; 2: Fries rearrangement;

DOI:10.1016/j.bmcl.2004.07.082

Reference yield:

acetic acid 3-hydroxy-5-isopropyl-phenyl ester → 2',6'-dihydroxy-4'-iso-propylacetophenone (257621-55-9)

Guidance literature:

With aluminium trichloride; In chlorobenzene; at 90 ℃;

DOI:10.1016/j.bmcl.2004.07.082

upstream raw materials:

3-isopropyl-1,5-diacetoxybenzene

3,5-dihydroxy-1-isopropylbenzene

Downstream raw materials:

2',6'-dihydroxy-4'-iso-propylacetophenone 2'-O-(2,3,4,6-O-tetraacetyl)-β-D-glucopyranoside