34993-66-3

Usage

Molecular weight

152.19 g/mol

Appearance

White or off-white crystalline solid

Solubility

Soluble in water, ethanol, and acetone

Melting point

69-71°C

Boiling point

285-290°C

Density

1.16 g/cm3

Structure

A derivative of resorcinol with an isopropyl group attached to one of its carbon atoms

Skincare

Active ingredient in skin brightening and anti-aging treatments

Hair care

Ingredient in hair dyes and colorants for long-lasting color

Mechanism of action

Inhibits melanin production, reducing dark spots, hyperpigmentation, and uneven skin tone

Safety

Generally considered safe for use in cosmetics, but potential for skin irritation in some individuals

Regulatory status

Approved for use in cosmetics by the FDA and other regulatory agencies

Chemical class

Aromatic alcohols

Upstream product

• 73109-76-9 5-isopropyl-1,3-dimethoxybenzene 
• 3509-22-6 1,3-bis-(α-hydroperoxy-isopropyl)-5-isopropyl-benzene 
• 785715-42-6 2-Hydroxy-6-isopropyl-4-oxo-cyclohex-2-enecarboxylic acid ethyl ester 
• 74732-80-2 4-Benzenesulfinyl-5-isopropyl-cyclohexane-1,3-dione 
• 717-74-8 1,3,5-triisopropyl benzene 
• 39508-15-1 3,5-dimethoxy-α-methylstyrene 
• 18456-87-6 5-isopropyl-1,3-cyclohexanedione 

Downstream Products

• 73109-86-1 2-(N-Benzyl-1,2,3,6-tetrahydro-4-pyridyl)-5-isopropyl resorcinol hydrochloride 
• 73109-88-3 2-(N-Isopropyl-1,2,3,6-tetrahydro-4-pyridyl)-5-isopropyl resorcinol hydrochloride 
• 1415357-94-6 2-iodo-5-isopropylbenzene-1,3-diol 
• 1415357-90-2 C₁₅H₂₅IO₂Si 
• 251452-43-4 3-hydroxy-5-benzoyloxy-1-isopropylbenzene 
• 257621-35-5 2',6'-dihydroxy-4'-iso-propylacetophenone 2'-O-(2,3,4,6-O-tetraacetyl)-β-D-glucopyranoside 
• 257621-55-9 2',6'-dihydroxy-4'-iso-propylacetophenone 
• 97025-07-5 3-isopropyl-1,5-diacetoxybenzene 

Relevant academic research and scientific papers

Dehydrogenative Formation of Resorcinol Derivatives Using Pd/C-Ethylene Catalytic System

The conversion of substituted 1,3-cyclohexanediones to the alkyl ethers of resorcinol using a Pd/C-ethylene system is reported. In these reactions, ethylene works as a hydrogen acceptor. The efficient synthesis of resveratrol was achieved using this protocol as a key step. In addition, the direct formation of substituted resorcinols was carried out by adding K2CO3 into the reaction media.

Chromanol derivatives - A novel class of CETP inhibitors

Based on our former development candidate BAY 38-1315, optimization efforts led to the discovery of a novel chemical class of orally active cholesteryl ester transfer protein (CETP) inhibitors. The chromanol derivative 19b is a highly potent CETP inhibitor with favorable pharmacokinetic properties suitable for clinical studies. Chemical process optimization furnished a robust synthesis for a kilogram-scale process.

Aerobic oxidation of 1,3,5-triisopropylbenzene using N-hydroxyphthalimide (NHPI) as key catalyst

The first systematic study on the aerobic oxidation of 1,3,5- triisopropylbenzene was examined by the use of N-hydroxyphthalimide (NHPI) as a key catalyst. It was found that 1,3,5-triisopropylbenzene was efficiently oxidized with O2 in the presence of a catalytic amount of NHPI and azobisisobutyronitrile (AIBN) at 75°C. Upon treatment of the resulting products with sulfuric acid followed by acetic anhydride led to 5-acetoxy-1,3-diisopropylbenzene and 3,5-diacetoxy-1-isopropylbenzene as major products and a small amount of 1,3,5-triacetoxybenzene. When t-butylperoxypivalate (BPP) was employed as a radical initiator, the oxidation could be achieved in good yield even at 50°C. This oxidation provides a facile method for preparing phenol derivatives bearing an isopropyl moiety, which can be used as pharmaceutical starting materials.

A New Route to 5-Substituted Resorcinols and Related Systems

Michael-type additions of phenylsulphinylacetate esters to αβ-unsaturated ketones produce cyclohexane-1,3-dione derivatives, which, after thermal elimination of benzenesulphenic acid, give the corresponding 5-substituted resorcinols, such as olivetol.The scope of this entry into other aromatic systems, such as 3,5-disubstituted and 2,3,5-trisubstituted phenols and orsellinic acid has been explored.

2-(N-phenethyl-4-piperidino)-5-pentyl resorcinol

This invention provides 2-(N-substituted piperidino)-5-alkyl resorcinols of the structure STR1 wherein R1 is H, loweralkyl, loweralkynyl or aralkyl; R2 and R3 are each H or when taken together R2 R3 =CH2 CH2 ; R4 is a C1 -C10 alkyl and R5 is H or loweralkyl, and the pharmaceutically acceptable salts thereof. These compounds are useful as antisecretory agents.