(αS)-α-[[(4-chlorophenyl)sulfonyl]amino]cyclohexaneacetic acid

Base Information

• Chemical Name: (αS)-α-[[(4-chlorophenyl)sulfonyl]amino]cyclohexaneacetic acid
• CAS No.: 635291-32-6
• Molecular Formula: C₁₄H₁₈ClNO₄S
• Molecular Weight: 331.82
• Mol file: 635291-32-6.mol

Synonyms:(αS)-α-[[(4-chlorophenyl)sulfonyl]amino]cyclohexaneacetic acid

Chemical Property of (αS)-α-[[(4-chlorophenyl)sulfonyl]amino]cyclohexaneacetic acid

Chemical Property:

Purity/Quality:

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MSDS Files:

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Technology Process of (αS)-α-[[(4-chlorophenyl)sulfonyl]amino]cyclohexaneacetic acid

There total 1 articles about (αS)-α-[[(4-chlorophenyl)sulfonyl]amino]cyclohexaneacetic acid which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

(2S)-amino(cyclohexyl)ethanoic acid (14328-51-9) + 4-chlorobenzenesulfonyl chloride (98-60-2) → (αS)-α-[[(4-chlorophenyl)sulfonyl]amino]cyclohexaneacetic acid (635291-32-6)

Guidance literature:

(2S)-amino(cyclohexyl)ethanoic acid; 4-chlorobenzenesulfonyl chloride; With sodium hydroxide; In tetrahydrofuran; water; at 25 ℃; for 24h;

With hydrogenchloride; In tetrahydrofuran; water; pH=2;

Reference yield: 37.0%

(αS)-α-[[(4-chlorophenyl)sulfonyl]amino]cyclohexaneacetic acid (635291-32-6) → 4-chloro-N-[(1S)-1-cyclohexyl-2-hydroxyethyl] benzenesulfonamide (635291-24-6)

Guidance literature:

With lithium aluminium tetrahydride; In tetrahydrofuran; at 0 - 25 ℃; for 24h;

upstream raw materials:

(2S)-amino(cyclohexyl)ethanoic acid

4-chlorobenzenesulfonyl chloride

Downstream raw materials:

4-chloro-N-[(1S)-1-cyclohexyl-2-hydroxyethyl] benzenesulfonamide