(1S,2R)-1-benzyl-N-(2-hydroxy-1-phenylethyl)-2-methylazetidine-2-carboxamide

Base Information

Chemical Name:(1S,2R)-1-benzyl-N-(2-hydroxy-1-phenylethyl)-2-methylazetidine-2-carboxamide
CAS No.:1384745-35-0
Molecular Formula:C₂₀H₂₄N₂O₂
Molecular Weight:324.423
Hs Code.:

Synonyms:(1S,2R)-1-benzyl-N-(2-hydroxy-1-phenylethyl)-2-methylazetidine-2-carboxamide

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Chemical Property of (1S,2R)-1-benzyl-N-(2-hydroxy-1-phenylethyl)-2-methylazetidine-2-carboxamide

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Technology Process of (1S,2R)-1-benzyl-N-(2-hydroxy-1-phenylethyl)-2-methylazetidine-2-carboxamide

There total 3 articles about (1S,2R)-1-benzyl-N-(2-hydroxy-1-phenylethyl)-2-methylazetidine-2-carboxamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: C₁₂H₁₅NO₂*ClH

: 20989-17-7
(2S)-2-phenylglycinol

: 1384745-35-0
(1S,2R)-1-benzyl-N-(2-hydroxy-1-phenylethyl)-2-methylazetidine-2-carboxamide

: 1384745-34-9
(1S,2S)-1-benzyl-N-(2-hydroxy-1-phenylethyl)-2-methylazetidine-2-carboxamide

Guidance literature:: With N-ethyl-N,N-diisopropylamine; HATU; In tetrahydrofuran; at 25 ℃; Inert atmosphere;
DOI:10.1016/j.tetasy.2012.05.006

Reference yield:

: 1269460-95-8
C₁₆H₂₄ClNO₂

: 1384745-35-0
(1S,2R)-1-benzyl-N-(2-hydroxy-1-phenylethyl)-2-methylazetidine-2-carboxamide

Guidance literature:: Multi-step reaction with 3 steps

1.1: potassium tert-butylate / tetrahydrofuran / Inert atmosphere

2.1: trifluoroacetic acid / dichloromethane / 0 - 25 °C / Inert atmosphere

2.2: Inert atmosphere

3.1: N-ethyl-N,N-diisopropylamine; HATU / tetrahydrofuran / 25 °C / Inert atmosphere

With potassium tert-butylate; N-ethyl-N,N-diisopropylamine; HATU; trifluoroacetic acid; In tetrahydrofuran; dichloromethane;
DOI:10.1016/j.tetasy.2012.05.006

Reference yield:

: 1269460-98-1
C₁₆H₂₃NO₂

: 1384745-35-0
(1S,2R)-1-benzyl-N-(2-hydroxy-1-phenylethyl)-2-methylazetidine-2-carboxamide

Guidance literature:: Multi-step reaction with 2 steps

1.1: trifluoroacetic acid / dichloromethane / 0 - 25 °C / Inert atmosphere

1.2: Inert atmosphere

2.1: N-ethyl-N,N-diisopropylamine; HATU / tetrahydrofuran / 25 °C / Inert atmosphere

With N-ethyl-N,N-diisopropylamine; HATU; trifluoroacetic acid; In tetrahydrofuran; dichloromethane;
DOI:10.1016/j.tetasy.2012.05.006