(1S,2R)-(9H-fluoren-9-yl)methyl 2-(2-hydroxy-1-phenylethylcarbamoyl)-2-methylazetidine-1-carboxylate

Base Information

Chemical Name:(1S,2R)-(9H-fluoren-9-yl)methyl 2-(2-hydroxy-1-phenylethylcarbamoyl)-2-methylazetidine-1-carboxylate
CAS No.:1384745-41-8
Molecular Formula:C₂₈H₂₈N₂O₄
Molecular Weight:456.541
Hs Code.:

Synonyms:(1S,2R)-(9H-fluoren-9-yl)methyl 2-(2-hydroxy-1-phenylethylcarbamoyl)-2-methylazetidine-1-carboxylate

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Chemical Property of (1S,2R)-(9H-fluoren-9-yl)methyl 2-(2-hydroxy-1-phenylethylcarbamoyl)-2-methylazetidine-1-carboxylate

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Technology Process of (1S,2R)-(9H-fluoren-9-yl)methyl 2-(2-hydroxy-1-phenylethylcarbamoyl)-2-methylazetidine-1-carboxylate

There total 7 articles about (1S,2R)-(9H-fluoren-9-yl)methyl 2-(2-hydroxy-1-phenylethylcarbamoyl)-2-methylazetidine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 28920-43-6
(fluorenylmethoxy)carbonyl chloride

: C₁₃H₁₈N₂O₂

: 1384745-41-8
(1S,2R)-(9H-fluoren-9-yl)methyl 2-(2-hydroxy-1-phenylethylcarbamoyl)-2-methylazetidine-1-carboxylate

Guidance literature:: With N-ethyl-N,N-diisopropylamine; In acetonitrile; at 0 - 25 ℃; Inert atmosphere;
DOI:10.1016/j.tetasy.2012.05.006

Reference yield:

: 1269460-89-0
C₁₆H₂₅NO₃

: 1384745-41-8
(1S,2R)-(9H-fluoren-9-yl)methyl 2-(2-hydroxy-1-phenylethylcarbamoyl)-2-methylazetidine-1-carboxylate

Guidance literature:: Multi-step reaction with 6 steps

1.1: thionyl chloride / dichloromethane

2.1: potassium tert-butylate / tetrahydrofuran / Inert atmosphere

3.1: trifluoroacetic acid / dichloromethane / 0 - 25 °C / Inert atmosphere

3.2: Inert atmosphere

4.1: N-ethyl-N,N-diisopropylamine; HATU / tetrahydrofuran / 25 °C / Inert atmosphere

5.1: hydrogenchloride; palladium 10% on activated carbon; hydrogen / ethanol; water / 25 °C / 760.05 Torr

5.2: Inert atmosphere

6.1: N-ethyl-N,N-diisopropylamine / acetonitrile / 0 - 25 °C / Inert atmosphere

With hydrogenchloride; thionyl chloride; palladium 10% on activated carbon; potassium tert-butylate; hydrogen; N-ethyl-N,N-diisopropylamine; HATU; trifluoroacetic acid; In tetrahydrofuran; ethanol; dichloromethane; water; acetonitrile;
DOI:10.1016/j.tetasy.2012.05.006

Reference yield:

: 1269460-95-8
C₁₆H₂₄ClNO₂

: 1384745-41-8
(1S,2R)-(9H-fluoren-9-yl)methyl 2-(2-hydroxy-1-phenylethylcarbamoyl)-2-methylazetidine-1-carboxylate

Guidance literature:: Multi-step reaction with 5 steps

1.1: potassium tert-butylate / tetrahydrofuran / Inert atmosphere

2.1: trifluoroacetic acid / dichloromethane / 0 - 25 °C / Inert atmosphere

2.2: Inert atmosphere

3.1: N-ethyl-N,N-diisopropylamine; HATU / tetrahydrofuran / 25 °C / Inert atmosphere

4.1: hydrogenchloride; palladium 10% on activated carbon; hydrogen / ethanol; water / 25 °C / 760.05 Torr

4.2: Inert atmosphere

5.1: N-ethyl-N,N-diisopropylamine / acetonitrile / 0 - 25 °C / Inert atmosphere

With hydrogenchloride; palladium 10% on activated carbon; potassium tert-butylate; hydrogen; N-ethyl-N,N-diisopropylamine; HATU; trifluoroacetic acid; In tetrahydrofuran; ethanol; dichloromethane; water; acetonitrile;
DOI:10.1016/j.tetasy.2012.05.006