Technology Process of ((1S,2R,3S)-2-chloro-3-phenylcyclopropyl)methanol
There total 5 articles about ((1S,2R,3S)-2-chloro-3-phenylcyclopropyl)methanol which
guide to synthetic route it.
The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:
synthetic route:
- Guidance literature:
-
(2E)-3-phenyl-2-propen-1-ol;
With
(4R,5R)-2-butyl-N4,N4,N5,N5-tetramethyl-1,3,2-dioxaborolane-4,5-dicarboxamide; diethylzinc; zinc trifluoromethanesulfonate;
In
diethyl ether; dichloromethane;
for 1h;
Sealed tube;
Inert atmosphere;
bromodichloromethane;
In
diethyl ether; dichloromethane;
at -42 - 20 ℃;
for 15h;
Reagent/catalyst;
stereoselective reaction;
Sealed tube;
Inert atmosphere;
DOI:10.1021/acs.organomet.1c00631
- Guidance literature:
-
chlorodiiodomethane;
With
diethylzinc;
In
dichloromethane;
at -78 ℃;
for 0.166667h;
Inert atmosphere;
(2E)-3-phenyl-2-propen-1-ol;
With
(4R,5R)-2-butyl-N4,N4,N5,N5-tetramethyl-1,3,2-dioxaborolane-4,5-dicarboxamide;
In
dichloromethane;
at -40 ℃;
for 16h;
Temperature;
Concentration;
enantioselective reaction;
Inert atmosphere;
Darkness;
DOI:10.1002/chem.201202528
- Guidance literature:
-
bromodiiodomethane; chlorodiiodomethane;
With
diethylzinc;
In
dichloromethane;
at -78 ℃;
for 0.166667h;
Inert atmosphere;
(2E)-3-phenyl-2-propen-1-ol;
With
(4R,5R)-2-butyl-N4,N4,N5,N5-tetramethyl-1,3,2-dioxaborolane-4,5-dicarboxamide;
In
dichloromethane;
at -78 - -40 ℃;
for 15h;
Temperature;
Concentration;
enantioselective reaction;
Inert atmosphere;
Darkness;
DOI:10.1002/chem.201202528
