(R)-tert-butyl 4-(5-(2-fluoro-4-(methylsulfonylmethyl)benzyloxy)pyrimidin-2-yl)-3-methylpiperazine-1-carboxylate

Base Information

Chemical Name:(R)-tert-butyl 4-(5-(2-fluoro-4-(methylsulfonylmethyl)benzyloxy)pyrimidin-2-yl)-3-methylpiperazine-1-carboxylate
CAS No.:1272974-20-5
Molecular Formula:C₂₃H₃₁FN₄O₅S
Molecular Weight:494.587
Hs Code.:

Synonyms:(R)-tert-butyl 4-(5-(2-fluoro-4-(methylsulfonylmethyl)benzyloxy)pyrimidin-2-yl)-3-methylpiperazine-1-carboxylate

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Chemical Property of (R)-tert-butyl 4-(5-(2-fluoro-4-(methylsulfonylmethyl)benzyloxy)pyrimidin-2-yl)-3-methylpiperazine-1-carboxylate

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Technology Process of (R)-tert-butyl 4-(5-(2-fluoro-4-(methylsulfonylmethyl)benzyloxy)pyrimidin-2-yl)-3-methylpiperazine-1-carboxylate

There total 7 articles about (R)-tert-butyl 4-(5-(2-fluoro-4-(methylsulfonylmethyl)benzyloxy)pyrimidin-2-yl)-3-methylpiperazine-1-carboxylate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 83.0%

: 1272974-21-6
(R)-tert-butyl-4-(5-(2-fluoro-4-(hydroxymethyl)benzyloxy)pyrimidin-2-yl)-3-methylpiperazine-1-carboxylate

: 124-63-0
methanesulfonyl chloride

: 1272974-20-5
(R)-tert-butyl 4-(5-(2-fluoro-4-(methylsulfonylmethyl)benzyloxy)pyrimidin-2-yl)-3-methylpiperazine-1-carboxylate

Guidance literature:: (R)-tert-butyl-4-(5-(2-fluoro-4-(hydroxymethyl)benzyloxy)pyrimidin-2-yl)-3-methylpiperazine-1-carboxylate; methanesulfonyl chloride; With N-ethyl-N,N-diisopropylamine; In dichloromethane; at 0 ℃; for 1h; Inert atmosphere;

With lithium iodide; In 1,4-dioxane; at 20 - 60 ℃;

With sodium methansulfinate; In N,N-dimethyl-formamide; at 22 ℃; for 1h;

Reference yield: 81.0%

: 1272973-67-7
(R)-tert-butyl4-(5-(benzyloxy)pyrimidin-2-yl)-3-methylpiperazine-1-carboxylate

: C₉H₁₁FO₃S

: 1272974-20-5
(R)-tert-butyl 4-(5-(2-fluoro-4-(methylsulfonylmethyl)benzyloxy)pyrimidin-2-yl)-3-methylpiperazine-1-carboxylate

Guidance literature:: With caesium carbonate; In acetonitrile; at 20 ℃; for 72h;
DOI:10.1021/jm5011012

Reference yield:

: 1272974-22-7
(R)-tert-butyl-4-(5-(2-fluoro-4-formylbenzyloxy)pyrimidin-2-yl)-3-methylpiperazine-1-carboxylate

: 1272974-20-5
(R)-tert-butyl 4-(5-(2-fluoro-4-(methylsulfonylmethyl)benzyloxy)pyrimidin-2-yl)-3-methylpiperazine-1-carboxylate

Guidance literature:: Multi-step reaction with 2 steps

1.1: ethanol; sodium tetrahydroborate / 3 h / 0 - 25 °C

2.1: N-ethyl-N,N-diisopropylamine / dichloromethane / 1 h / 0 °C / Inert atmosphere

2.2: 20 - 60 °C

2.3: open air / 1 h / 22 °C

With sodium tetrahydroborate; ethanol; N-ethyl-N,N-diisopropylamine; In dichloromethane;