Technology Process of terephthaloyldi(L-leucyl-L-proline methyl ester)
There total 4 articles about terephthaloyldi(L-leucyl-L-proline methyl ester) which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
2,2′-(terephthaloylbis(azanediyl))bis(4-methylpentanoic acid);
With
diisopropyl-carbodiimide;
In
dichloromethane;
at 20 ℃;
for 1h;
L-proline methyl ester monohydrochloride;
With
N-ethyl-N,N-diisopropylamine;
In
dichloromethane;
at 20 ℃;
for 16h;
DOI:10.1007/s00706-003-0029-x
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: 77 percent / diisopropylethylamine / CH2Cl2 / 16 h / 20 °C
2.1: 95 percent / aq. LiOH / 1,2-dimethoxy-ethane / 2 h / 20 °C
3.1: N,N'-diisopropylcarbodiimide / CH2Cl2 / 1 h / 20 °C
3.2: 58 percent / diisopropylethylamine / CH2Cl2 / 16 h / 20 °C
With
lithium hydroxide; N-ethyl-N,N-diisopropylamine; diisopropyl-carbodiimide;
In
1,2-dimethoxyethane; dichloromethane;
DOI:10.1007/s00706-003-0029-x
- Guidance literature:
-
Multi-step reaction with 3 steps
1.1: 77 percent / diisopropylethylamine / CH2Cl2 / 16 h / 20 °C
2.1: 95 percent / aq. LiOH / 1,2-dimethoxy-ethane / 2 h / 20 °C
3.1: N,N'-diisopropylcarbodiimide / CH2Cl2 / 1 h / 20 °C
3.2: 58 percent / diisopropylethylamine / CH2Cl2 / 16 h / 20 °C
With
lithium hydroxide; N-ethyl-N,N-diisopropylamine; diisopropyl-carbodiimide;
In
1,2-dimethoxyethane; dichloromethane;
DOI:10.1007/s00706-003-0029-x
