2,2′-(terephthaloylbis(azanediyl))bis(4-methylpentanoic acid)

Base Information

• Chemical Name: 2,2′-(terephthaloylbis(azanediyl))bis(4-methylpentanoic acid)
• CAS No.: 668479-47-8
• Molecular Formula: C₂₀H₂₈N₂O₆
• Molecular Weight: 392.452
• Mol file: 668479-47-8.mol

Synonyms:2,2′-(terephthaloylbis(azanediyl))bis(4-methylpentanoic acid)

Chemical Property of 2,2′-(terephthaloylbis(azanediyl))bis(4-methylpentanoic acid)

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of 2,2′-(terephthaloylbis(azanediyl))bis(4-methylpentanoic acid)

There total 4 articles about 2,2′-(terephthaloylbis(azanediyl))bis(4-methylpentanoic acid) which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 95.0%

dimethyl 2,2′-(terephthaloylbis(azanediyl))bis(4-methylpentanoate) (668479-45-6) → 2,2′-(terephthaloylbis(azanediyl))bis(4-methylpentanoic acid) (668479-47-8)

Guidance literature:

With lithium hydroxide; In 1,2-dimethoxyethane; at 20 ℃; for 2h;

DOI:10.1007/s00706-003-0029-x

Reference yield:

methyl (L)-leucinate hydrochloride (7517-19-3) + terephthaloyl chloride (100-20-9) → 2,2′-(terephthaloylbis(azanediyl))bis(4-methylpentanoic acid) (668479-47-8)

Guidance literature:

Multi-step reaction with 2 steps

1: triethylamine / dichloromethane / 24 h / 20 °C

2: sodium hydroxide / methanol; water / 8 h / 20 °C

With triethylamine; sodium hydroxide; In methanol; dichloromethane; water;

DOI:10.1039/c4ce00605d

Reference yield:

methyl (L)-leucinate hydrochloride (7517-19-3) → 2,2′-(terephthaloylbis(azanediyl))bis(4-methylpentanoic acid) (668479-47-8)

Guidance literature:

Multi-step reaction with 2 steps

1: 77 percent / diisopropylethylamine / CH₂Cl₂ / 16 h / 20 °C

2: 95 percent / aq. LiOH / 1,2-dimethoxy-ethane / 2 h / 20 °C

With lithium hydroxide; N-ethyl-N,N-diisopropylamine; In 1,2-dimethoxyethane; dichloromethane;

DOI:10.1007/s00706-003-0029-x

upstream raw materials:

dimethyl 2,2′-(terephthaloylbis(azanediyl))bis(4-methylpentanoate)

methyl (L)-leucinate hydrochloride

terephthaloyl chloride

Downstream raw materials:

terephthaloyldi(L-leucyl-L-proline methyl ester)