3-pyrrolidinecarboxylic acid, 1-(3-chloro-4-fluorophenyl)-

Base Information

• Chemical Name: 3-pyrrolidinecarboxylic acid, 1-(3-chloro-4-fluorophenyl)-
• CAS No.: 696647-51-5
• Molecular Formula: C₁₁H₉ClFNO₃
• Molecular Weight: 257.649
• Hs Code.: 2933790090
• Mol file: 696647-51-5.mol

Synonyms:1-(3-chloro-4-fluorophenyl)-5-oxopyrrolidine-3-carboxylic acid

Chemical Property of 3-pyrrolidinecarboxylic acid, 1-(3-chloro-4-fluorophenyl)-

Chemical Property:

Purity/Quality:

98%min ^*data from raw suppliers

1-(3-Chloro-4-fluorophenyl)-5-oxopyrrolidine-3-carboxylic acid ^*data from reagent suppliers

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Technology Process of 3-pyrrolidinecarboxylic acid, 1-(3-chloro-4-fluorophenyl)-

There total 1 articles about 3-pyrrolidinecarboxylic acid, 1-(3-chloro-4-fluorophenyl)- which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

3-chloro-4-fluorophenylamine (367-21-5) + 2-methylenesuccinic acid (97-65-4,25119-64-6) → 1-(3-chloro-4-fluorophenyl)-5-oxopyrrolidine-3-carboxylic acid (696647-51-5)

Guidance literature:

for 0.333333h; Heating;

DOI:10.1016/j.tet.2007.01.058

Reference yield: 85.0%

1-(3-chloro-4-fluorophenyl)-5-oxopyrrolidine-3-carboxylic acid (696647-51-5) → [N-(3-chloro-4-fluorophenyl)pyrrolidin-3-yl]methanol (848317-71-5)

Guidance literature:

With sodium tetrahydroborate; iodine; In tetrahydrofuran; at 78 ℃; for 0.5h;

DOI:10.1016/j.tet.2007.01.058

Reference yield: 74.0%

1-(3-chloro-4-fluorophenyl)-5-oxopyrrolidine-3-carboxylic acid (696647-51-5) + 1,2-diamino-benzene (95-54-5) → 4-(1H-benzo[d]imidazol-2-yl)-1-(3-chloro-4-fluorophenyl)pyrrolidin-2-one

Guidance literature:

With polyphosphoric acid; at 150 - 160 ℃;

DOI:10.1111/cbdd.13751

upstream raw materials:

3-chloro-4-fluorophenylamine

2-methylenesuccinic acid

Downstream raw materials:

[N-(3-chloro-4-fluorophenyl)pyrrolidin-3-yl]methanol

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