1-(3-Chloro-4-fluorophenyl)-3-pyrrolidinemethanol

Base Information

Chemical Name:1-(3-Chloro-4-fluorophenyl)-3-pyrrolidinemethanol
CAS No.:848317-71-5
Molecular Formula:C11H13ClFNO
Molecular Weight:229.682
Hs Code.:
DSSTox Substance ID:DTXSID301231855

Synonyms:848317-71-5;1-(3-Chloro-4-fluorophenyl)-3-pyrrolidinemethanol;DTXSID301231855;AKOS005288172

Suppliers and Price of 1-(3-Chloro-4-fluorophenyl)-3-pyrrolidinemethanol

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Business phase:: The product has achieved commercial mass production^*data from LookChem market partment

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Chemical Property of 1-(3-Chloro-4-fluorophenyl)-3-pyrrolidinemethanol

Chemical Property:

XLogP3:2.5
Hydrogen Bond Donor Count:1
Hydrogen Bond Acceptor Count:3
Rotatable Bond Count:2
Exact Mass:229.0669699
Heavy Atom Count:15
Complexity:217

Purity/Quality:

Safty Information:

Pictogram(s):
Hazard Codes:

MSDS Files:

Useful:

Canonical SMILES:C1CN(CC1CO)C2=CC(=C(C=C2)F)Cl

Technology Process of 1-(3-Chloro-4-fluorophenyl)-3-pyrrolidinemethanol

There total 4 articles about 1-(3-Chloro-4-fluorophenyl)-3-pyrrolidinemethanol which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 85.0%

: 696647-51-5
1-(3-chloro-4-fluorophenyl)-5-oxopyrrolidine-3-carboxylic acid

: 848317-71-5
[N-(3-chloro-4-fluorophenyl)pyrrolidin-3-yl]methanol

Guidance literature:: With sodium tetrahydroborate; iodine; In tetrahydrofuran; at 78 ℃; for 0.5h;
DOI:10.1016/j.tet.2007.01.058

Reference yield: 78.0%

: 618070-34-1
N-(3-chloro-4-fluorophenyl)-2-oxo-pyrrolidine-3-carboxylic acid

: 848317-71-5
[N-(3-chloro-4-fluorophenyl)pyrrolidin-3-yl]methanol

Guidance literature:: With sodium tetrahydroborate; iodine; In tetrahydrofuran; at 25 ℃; for 2h;
DOI:10.1016/j.tetlet.2004.12.107

Reference yield:

: 367-21-5
3-chloro-4-fluorophenylamine

: 848317-71-5
[N-(3-chloro-4-fluorophenyl)pyrrolidin-3-yl]methanol

Guidance literature:: Multi-step reaction with 2 steps

1: 78 percent / 25 °C

2: 78 percent / NaBH₄; iodine / tetrahydrofuran / 2 h / 25 °C

With sodium tetrahydroborate; iodine; In tetrahydrofuran;
DOI:10.1016/j.tet.2007.01.058