N-{2-(1-benzyl-1H-1,2,3-triazol-4-yl)propan-2-yl}-3-(trifluoromethyl)benzamide

Base Information

Chemical Name:N-{2-(1-benzyl-1H-1,2,3-triazol-4-yl)propan-2-yl}-3-(trifluoromethyl)benzamide
CAS No.:1646184-00-0
Molecular Formula:C₂₀H₁₉F₃N₄O
Molecular Weight:388.392
Hs Code.:

Synonyms:N-{2-(1-benzyl-1H-1,2,3-triazol-4-yl)propan-2-yl}-3-(trifluoromethyl)benzamide

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Chemical Property of N-{2-(1-benzyl-1H-1,2,3-triazol-4-yl)propan-2-yl}-3-(trifluoromethyl)benzamide

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Technology Process of N-{2-(1-benzyl-1H-1,2,3-triazol-4-yl)propan-2-yl}-3-(trifluoromethyl)benzamide

There total 4 articles about N-{2-(1-benzyl-1H-1,2,3-triazol-4-yl)propan-2-yl}-3-(trifluoromethyl)benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 87.0%

: 1310826-33-5
2-(1-benzyl-1H-1,2,3-triazol-4-yl)propan-2-amine

: 2251-65-2
3-(Trifluoromethyl)benzoyl chloride

: 1646184-00-0
N-{2-(1-benzyl-1H-1,2,3-triazol-4-yl)propan-2-yl}-3-(trifluoromethyl)benzamide

Guidance literature:: With triethylamine; In dichloromethane; at 0 - 20 ℃; for 12h; Inert atmosphere; Schlenk technique;
DOI:10.1002/chem.201403019

Reference yield:

: 2978-58-7
1,1-dimethylprop-3-ynylamine

: 1646184-00-0
N-{2-(1-benzyl-1H-1,2,3-triazol-4-yl)propan-2-yl}-3-(trifluoromethyl)benzamide

Guidance literature:: Multi-step reaction with 2 steps

1: copper(ll) sulfate pentahydrate; sodium L-ascorbate / tert-butyl alcohol; water / 24 h / 20 °C / Schlenk technique; Inert atmosphere

2: triethylamine / dichloromethane / 12 h / 0 - 20 °C / Inert atmosphere; Schlenk technique

With copper(ll) sulfate pentahydrate; sodium L-ascorbate; triethylamine; In dichloromethane; water; tert-butyl alcohol; 1: |Huisgen Cycloaddition;
DOI:10.1002/chem.201403019

Reference yield:

: 622-79-7
benzyl azide

: 1646184-00-0
N-{2-(1-benzyl-1H-1,2,3-triazol-4-yl)propan-2-yl}-3-(trifluoromethyl)benzamide

Guidance literature:: Multi-step reaction with 2 steps

1: copper(ll) sulfate pentahydrate; sodium L-ascorbate / tert-butyl alcohol; water / 24 h / 20 °C / Schlenk technique; Inert atmosphere

2: triethylamine / dichloromethane / 12 h / 0 - 20 °C / Inert atmosphere; Schlenk technique

With copper(ll) sulfate pentahydrate; sodium L-ascorbate; triethylamine; In dichloromethane; water; tert-butyl alcohol; 1: |Huisgen Cycloaddition;
DOI:10.1002/chem.201403019