1310826-33-5

Basic information

• Product Name: 2-(1-benzyl-1H-1,2,3-triazol-4-yl)propan-2-amine
• Synonyms: 2-(1-benzyl-1H-1,2,3-triazol-4-yl)propan-2-amine
• CAS NO: 1310826-33-5
• Molecular Weight: 216.286
• Mol File: 1310826-33-5.mol
• Article Data: 6

Chemical Properties

• CAS DataBase Reference: 2-(1-benzyl-1H-1,2,3-triazol-4-yl)propan-2-amine(CAS DataBase Reference)
• NIST Chemistry Reference: 2-(1-benzyl-1H-1,2,3-triazol-4-yl)propan-2-amine(1310826-33-5)
• EPA Substance Registry System: 2-(1-benzyl-1H-1,2,3-triazol-4-yl)propan-2-amine(1310826-33-5)

Safety Data

• Hazardous Substances Data: 1310826-33-5(Hazardous Substances Data)

Upstream product

• 622-79-7 benzyl azide 
• 113486-06-9 (1,1-dimethyl-prop-2-ynyl)-carbamic acid tert-butyl ester 
• 2978-58-7 1,1-dimethylprop-3-ynylamine 
• 100-39-0 benzyl bromide 

Downstream Products

• 1646184-06-6 ethyl 2’-{(2-[1-benzyl-1H-1,2,3-triazol-4-yl]propan-2-yl)carbamoyl}1[1,1’-biphenyl]-4-carboxylate 
• 1646184-27-1 diethyl 2’-{(2-[1-benzyl-1H-1,2,3-triazol-4-yl]propan-2-yl)carbamoyl}-[1,1’:3’,1’’-terphenyl]-4,4’’-dicarboxylate 
• 1646184-28-2 diethyl 2’-((2-(1-benzyl-1H-1,2,3-triazol-4-yl)propan-2-yl)carbamoyl)-5’-phenyl-[1,1’:3‘,1“-terphenyl]-4,4”-dicarboxylate 
• 1646184-29-3 diethyl 2’-{(2-(1-benzyl-1H-1,2,3-triazol-4-yl)propan-2-yl)carbamoyl}-5’-methoxy-[1,1’:3’,1’’-terphenyl]-4,4”-dicarboxylate 
• 1646184-09-9 ethyl 2’-{(2-(1-benzyl-1H-1,2,3-triazol-4-yl)propan-2-yl)carbamoyl}-5’-methyl-[1,1’-biphenyl]-4-carboxylate 
• 1646184-30-6 diethyl 2’-{(2-(1-benzyl-1H-1,2,3-triazol-4-yl)propan-2-yl)carbamoyl}-5’-methyl-[1,1’:3‘,1“-terphenyl]-4,4”-dicarboxylate 
• 1646184-10-2 ethyl 2’-{(2-(1-benzyl-1H-1,2,3-triazol-4-yl)propan-2-yl)carbamoyl}-4’-methoxy-[1,1’-biphenyl]-4-carboxylate 
• 1646184-11-3 ethyl 2’-{(2-(1-benzyl-1H-1,2,3-triazol-4-yl)propan-2-yl)carbamoyl}-4’-methyl-[1,1’-biphenyl]-4-carboxylate 
• 1646184-12-4 ethyl 2’-{(2-(1-benzyl-1H-1,2,3-triazol-4-yl)propan-2-yl)carbamoyl}-4’-(trifluoromethyl)-[1,1’-biphenyl]-4-carboxylate 
• 1646184-13-5 ethyl 2’-{(2-(1-benzyl-1H-1,2,3-triazol-4-yl)propan-2-yl)carbamoyl}-[1,1‘:4’,1”-terphenyl]-4-carboxylate 
• 1646184-14-6 ethyl 2’-{(2-(1-benzyl-1H-1,2,3-triazol-4-yl)propan-2-yl)carbamoyl}-4’-chloro-[1,1’-biphenyl]-4-carboxylate 
• 1646184-16-8 ethyl 2’-{(2-(1-benzyl-1H-1,2,3-triazol-4-yl)propan-2-yl)carbamoyl}-3’-(trifluoromethyl)-[1,1’-biphenyl]-4-carboxylate 
• 1623775-39-2 N-{2-(1-benzyl-1H-1,2,3-triazol-4-yl)propan-2-yl}-4-(trifluoromethyl)-[1,1’-biphenyl]-2-carboxamide 
• 1646183-99-4 N-[2-(1-benzyl-1H-1,2,3-triazol-4-yl)propan-2-yl]-3-methoxybenzamide 

Relevant articles and documents

NURR1 RECEPTOR MODULATORS

Described herein, inter alia, are Nurr1 receptor modulators and uses thereof. In an aspect is provided a method for treating a disease associated with dysregulation and/or degeneration of dopaminergic neurons in the central nervous system of a subject in need thereof, the method including administering to the subject in need thereof a therapeutically effective amount of a compound described herein.

Iron-catalyzed C(sp2)-H and C(sp3)-H arylation by triazole assistance

Modular 1,2,3-triazoles enabled iron-catalyzed C-H arylations with broad scope. The novel triazole-based bidentate auxiliary is easily accessible in a highly modular fashion and allowed for user-friendly iron-catalyzed C(sp 2)-H functionalizations of arenes and alkenes with excellent chemo- and diastereoselectivities. The versatile iron catalyst also proved applicable for challenging C(sp3)-H functionalizations, and proceeds by an organometallic mode of action. The triazole-assisted C-H activation strategy occurred under remarkably mild reaction conditions, and the auxiliary was easily removed in a traceless fashion. Intriguingly, the triazole group proved superior to previously used auxiliaries. With a little help: A versatile iron catalyst allows the arylation of C(sp2)-H and C(sp3)-H bonds in the presence of a modular and removable triazolyldimethylmethyl (TAM) auxiliary, whose structure can be varied through 1,3-dipolar azide-alkyne cycloadditions.

An abnormal N-heterocyclic carbene-copper(I) complex in click chemistry

Herein we report the synthesis of a copper(I) chloro complex using an abnormal N-heterocyclic carbene (aNHC) salt, 1,3-bis(2,6-diisopropylphenyl)-2,4- diphenylimidazolium. The Cu(aNHC) complex efficiently catalyzed Huisgen 1,3-dipolar cycloaddition reacti