4-fluoro-N-(1-hydroxy-3,3-spirocyclobutyl-1,3-dihydro-benzo[c][1,2]oxaborol-6-yl)-2-trifluoromethyl benzamide

Base Information

Chemical Name:4-fluoro-N-(1-hydroxy-3,3-spirocyclobutyl-1,3-dihydro-benzo[c][1,2]oxaborol-6-yl)-2-trifluoromethyl benzamide
CAS No.:1266121-69-0
Molecular Formula:C₁₈H₁₄BF₄NO₃
Molecular Weight:379.119
Hs Code.:

Synonyms:4-fluoro-N-(1-hydroxy-3,3-spirocyclobutyl-1,3-dihydro-benzo[c][1,2]oxaborol-6-yl)-2-trifluoromethyl benzamide

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Chemical Property of 4-fluoro-N-(1-hydroxy-3,3-spirocyclobutyl-1,3-dihydro-benzo[c][1,2]oxaborol-6-yl)-2-trifluoromethyl benzamide

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Technology Process of 4-fluoro-N-(1-hydroxy-3,3-spirocyclobutyl-1,3-dihydro-benzo[c][1,2]oxaborol-6-yl)-2-trifluoromethyl benzamide

There total 4 articles about 4-fluoro-N-(1-hydroxy-3,3-spirocyclobutyl-1,3-dihydro-benzo[c][1,2]oxaborol-6-yl)-2-trifluoromethyl benzamide which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 52.0%

: 1266121-86-1
6-amino-3,3-dimethyl-3H-benzo[c][1,2]oxaborol-1-ol acetate

: 189807-21-4
2-trifluoromethyl-4-fluorobenzoyl chloride

: 1266121-69-0
4-fluoro-N-(1-hydroxy-3,3-spirocyclobutyl-1,3-dihydro-benzo[c][1,2]oxaborol-6-yl)-2-trifluoromethyl benzamide

Guidance literature:: With triethylamine; In dichloromethane; at 0 - 20 ℃;

Reference yield:

: 244205-40-1
(2-bromophenyl)boronic acid

: 1266121-69-0
4-fluoro-N-(1-hydroxy-3,3-spirocyclobutyl-1,3-dihydro-benzo[c][1,2]oxaborol-6-yl)-2-trifluoromethyl benzamide

Guidance literature:: Multi-step reaction with 5 steps

1.1: toluene / 2 h / 50 °C

2.1: n-butyllithium / hexane; tetrahydrofuran / 0.67 h / -78 °C

2.2: 0.5 h / -78 °C

2.3: 0.5 h / 20 °C

3.1: nitric acid / nitrobenzene / -45 - -40 °C

4.1: hydrogen / 5% Pd(II)/C(eggshell) / tetrahydrofuran

5.1: triethylamine / dichloromethane / 0 - 20 °C

With n-butyllithium; hydrogen; nitric acid; triethylamine; 5% Pd(II)/C(eggshell); In tetrahydrofuran; hexane; dichloromethane; nitrobenzene; toluene;

Reference yield:

: 1008106-85-1
2-(2'-bromophenyl)-6-butyl[1,3,6,2]dioxazaborocan

: 1266121-69-0
4-fluoro-N-(1-hydroxy-3,3-spirocyclobutyl-1,3-dihydro-benzo[c][1,2]oxaborol-6-yl)-2-trifluoromethyl benzamide

Guidance literature:: Multi-step reaction with 4 steps

1.1: n-butyllithium / hexane; tetrahydrofuran / 0.67 h / -78 °C

1.2: 0.5 h / -78 °C

1.3: 0.5 h / 20 °C

2.1: nitric acid / nitrobenzene / -45 - -40 °C

3.1: hydrogen / 5% Pd(II)/C(eggshell) / tetrahydrofuran

4.1: triethylamine / dichloromethane / 0 - 20 °C

With n-butyllithium; hydrogen; nitric acid; triethylamine; 5% Pd(II)/C(eggshell); In tetrahydrofuran; hexane; dichloromethane; nitrobenzene;