2-(2-Bromophenyl)-6-butyl-1,3,6,2-dioxazaborolane

Base Information

• Chemical Name: 2-(2-Bromophenyl)-6-butyl-1,3,6,2-dioxazaborolane
• CAS No.: 1008106-85-1
• Molecular Formula: C14H21BBrNO2+
• Molecular Weight: 326.041
• Mol file: 1008106-85-1.mol

Synonyms:2-(2-Bromophenyl)-6-butyl-1,3,6,2-dioxazaborolane

Chemical Property of 2-(2-Bromophenyl)-6-butyl-1,3,6,2-dioxazaborolane

Chemical Property:

• PSA: 18.46000
• LogP: 2.23110

Purity/Quality:

99% ^*data from raw suppliers

2-(2-Bromophenyl)-6-butyl-1,3,6,2-dioxazaborolane 97% ^*data from reagent suppliers

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

SDS file from LookChem

Useful:

Technology Process of 2-(2-Bromophenyl)-6-butyl-1,3,6,2-dioxazaborolane

There total 1 articles about 2-(2-Bromophenyl)-6-butyl-1,3,6,2-dioxazaborolane which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 98.6%

n-butyldiethanolamine (102-79-4) + (2-bromophenyl)boronic acid (244205-40-1) → 2-(2'-bromophenyl)-6-butyl[1,3,6,2]dioxazaborocan (1008106-85-1)

Guidance literature:

In toluene; at 50 ℃; for 2h; Product distribution / selectivity;

Reference yield: 76.0%

Trimethyl borate (121-43-7,63156-11-6) + 2-(2'-bromophenyl)-6-butyl[1,3,6,2]dioxazaborocan (1008106-85-1) → [2-(dihydroxyboranyl)phenyl]boronic acid (13506-83-7)

Guidance literature:

2-(2'-bromophenyl)-6-butyl[1,3,6,2]dioxazaborocan; With n-butyllithium; In tetrahydrofuran; at -90 - -75 ℃; for 0.333333h;

Trimethyl borate; at -85 ℃; for 0.333333h;

With hydrogenchloride; In water; at -30 ℃;

DOI:10.1021/om500104w

Reference yield: 62.0%

2-(N,N-dimethylamino)ethanol (108-01-0) + 2-(2'-bromophenyl)-6-butyl[1,3,6,2]dioxazaborocan (1008106-85-1) + diphenylsilyl chloride (1631-83-0) → 3-[2-(N,N-dimethylamino)ethanolato]-1,3-dihydro-1,1-diphenyl-1,2,3-benzosiloxaborole

Guidance literature:

2-(2'-bromophenyl)-6-butyl[1,3,6,2]dioxazaborocan; With n-butyllithium; In tetrahydrofuran; hexane; at -90 - -80 ℃; for 0.333333h;

diphenylsilyl chloride; at -90 - -30 ℃;

2-(N,N-dimethylamino)ethanol; Further stages;

DOI:10.1021/acs.organomet.5b00265

upstream raw materials:

n-butyldiethanolamine

(2-bromophenyl)boronic acid

Downstream raw materials:

3,3-dimethylbenzo [c][1,2]oxaborol-1(3H)-ol

acoziborole

4-fluoro-N-(1-hydroxy-3,3-spirocyclobutyl-1,3-dihydro-benzo[c][1,2]oxaborol-6-yl)-2-trifluoromethyl benzamide

2-chloro-4-fluoro-N-(1-hydroxy-3,3-dimethyl-1,3-dihydro-benzo[c][1,2]oxaborol-6-yl)-benzamide

Refernces

• 1、 Tomsho, John W.,Pal, Arnab,Hall, Dennis G.,Benkovic, Stephen J.. "Ring structure and aromatic substituent effects on the p K a of the benzoxaborole pharmacophore". . p. 48 - 52. Retrieved 2012.
• 2、 -. "BORON-CONTAINING SMALL MOLECULES AS ANTIPROTOZOAL AGENTS". Page/Page column 128-129. . Retrieved 2011/02/24.