(S)-methyl 2-((S)-2-(dimethylamino)-3-methylbutanamido)-3-(4-hydroxy-phenyl)-propanoate

Base Information

• Chemical Name: (S)-methyl 2-((S)-2-(dimethylamino)-3-methylbutanamido)-3-(4-hydroxy-phenyl)-propanoate
• CAS No.: 1443226-24-1
• Molecular Formula: C₁₇H₂₆N₂O₄
• Molecular Weight: 322.404
• Mol file: 1443226-24-1.mol

Synonyms:(S)-methyl 2-((S)-2-(dimethylamino)-3-methylbutanamido)-3-(4-hydroxy-phenyl)-propanoate

Chemical Property of (S)-methyl 2-((S)-2-(dimethylamino)-3-methylbutanamido)-3-(4-hydroxy-phenyl)-propanoate

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (S)-methyl 2-((S)-2-(dimethylamino)-3-methylbutanamido)-3-(4-hydroxy-phenyl)-propanoate

There total 1 articles about (S)-methyl 2-((S)-2-(dimethylamino)-3-methylbutanamido)-3-(4-hydroxy-phenyl)-propanoate which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield: 53.0%

N,N-dimethyl-L-valine (2812-32-0) + L-Tyr-OMe (1080-06-4) → (S)-methyl 2-((S)-2-(dimethylamino)-3-methylbutanamido)-3-(4-hydroxy-phenyl)-propanoate (1443226-24-1)

Guidance literature:

With benzotriazol-1-ol; triethylamine; dicyclohexyl-carbodiimide; In acetonitrile; at -5 - 20 ℃; for 10h;

DOI:10.1002/chem.201203479

Reference yield: 39.0%

(S)-methyl 2-((S)-2-(dimethylamino)-3-methylbutanamido)-3-(4-hydroxy-phenyl)-propanoate (1443226-24-1) + 3-(4-Methoxyphenyl)-3-(trifluoromethyl)-3H-diazirine (891501-19-2) → rac-(S)-methyl-2-((S)-2-(dimethylamino)-3-methylbutanamido)-3-(4-(2,2,2-trifluoro-1-(4-methoxyphenyl)ethoxy)phenyl)propanoate + rac-(S)-methyl-2-((S)-2-(dimethylamino)-3-methylbutanamido)-3-(4-(2,2,2-trifluoro-1-(4-methoxyphenyl)ethoxy)phenyl)propanoate

Guidance literature:

In dichloromethane; at 20 ℃; for 2h; Inert atmosphere;

DOI:10.1002/chem.201203479

Reference yield:

(S)-methyl 2-((S)-2-(dimethylamino)-3-methylbutanamido)-3-(4-hydroxy-phenyl)-propanoate (1443226-24-1) + 3-(4-Methoxyphenyl)-3-(trifluoromethyl)-3H-diazirine (891501-19-2) → rac-(S)-methyl-2-((S)-2-(dimethylamino)-3-methylbutanamido)-3-(4-(2,2,2-trifluoro-1-(4-methoxyphenyl)ethoxy)phenyl)propanoate

Guidance literature:

In dichloromethane; for 2h; Irradiation; Inert atmosphere;

DOI:10.1002/chem.201203479

upstream raw materials:

N,N-dimethyl-L-valine

L-Tyr-OMe