2812-32-0

Basic information

• Product Name: N,N-DIMETHYL-L-VALINE
• Synonyms: N,N-DIMETHYL-L-VALINE;N,N-Dimethylvaline99%;N,N-Dimethyl-L-valine ,98%;L-N,N-Dimethylvaline;N,N-Dimethylvaline;N,N-Dimethylvaline hydrochloride;(S)-2-(DiMethylaMino)-3-Methylbutanoic acid;N,N-Dimethyvaline
• CAS NO: 2812-32-0
• Molecular Formula: C₇H₁₅NO₂
• Molecular Weight: 145.2
• Mol File: 2812-32-0.mol
• Article Data: 5

Chemical Properties

• Melting Point: 153℃
• Boiling Point: 209℃
• Flash Point: 80℃
• Appearance: /
• Density: 0.989
• Vapor Pressure: 0.084mmHg at 25°C
• Refractive Index: 1.453
• Storage Temp.: 2-8°C
• Solubility: DMSO (Slightly), Ethanol (Slightly), Methanol (Slightly)
• PKA: 2.39±0.18(Predicted)
• CAS DataBase Reference: N,N-DIMETHYL-L-VALINE(CAS DataBase Reference)
• NIST Chemistry Reference: N,N-DIMETHYL-L-VALINE(2812-32-0)
• EPA Substance Registry System: N,N-DIMETHYL-L-VALINE(2812-32-0)

Safety Data

• Hazardous Substances Data: 2812-32-0(Hazardous Substances Data)

Usage

Description

N,N-DIMETHYL-L-VALINE, also known as N,N-Dimethyl-L-valine, is a metabolite derived from L-Valine (V094205), an essential amino acid. It plays a significant role in various biological processes and has been the subject of research for its potential therapeutic effects.

Uses

Used in Pharmaceutical Applications:
N,N-DIMETHYL-L-VALINE is used as a therapeutic agent for its potential to attenuate arrhythmias and induce hypotensive effects. This application is based on its role as a metabolite of L-Valine, which has been studied for its effects on cardiovascular health.
Used in Research and Development:
N,N-DIMETHYL-L-VALINE is also used as a research compound in the development of new drugs and therapies targeting cardiovascular conditions. Its unique properties and metabolic relationship with L-Valine make it a valuable tool for understanding the underlying mechanisms of arrhythmias and hypertension, potentially leading to the discovery of novel treatments.

InChI:InChI=1/C7H15NO2/c1-5(2)6(7(9)10)8(3)4/h5-6H,1-4H3,(H,9,10)/t6-/m0/s1

Upstream product

• 1187551-28-5 grassystatin A 

Downstream Products

• 97800-78-7 N,N-Dimethyl-L-valine pentafluorophenyl ester 
• 97800-77-6 N,N-Dimethylvalin-(p-nitrophenyl)ester 
• 138406-50-5 (S)-2-Dimethylamino-3-methyl-butyric acid (S)-methoxycarbonyl-phenyl-methyl ester 
• 110417-88-4 dolastatin 10 
• 123884-00-4 dolastatin 15 
• 1105044-31-2 (2S,2'S)-[(1S,2S)-1,2-diphenylethane-1,2-diyl] bis[2-(dimethylamino)-3-methylbutanoate] 
• 120205-53-0 (3R,4S,5S)-tert-butyl 4-((S)-2-((S)-2-(dimethylamino)-3-methylbutanamido)-N,3-dimethylbutanamido)-3-methoxy-5-methylheptanoate 
• 149606-69-9 (3R,4S,5S)-4-{[(S)-2-((S)-2-Dimethylamino-3-methyl-butyrylamino)-3-phenyl-propionyl]-methyl-amino}-3-methoxy-5-methyl-heptanoic acid tert-butyl ester 

Relevant articles and documents

Pagoamide A, a Cyclic Depsipeptide Isolated from a Cultured Marine Chlorophyte, Derbesia sp., Using MS/MS-Based Molecular Networking

A thiazole-containing cyclic depsipeptide with 11 amino acid residues, named pagoamide A (1), was isolated from laboratory cultures of a marine Chlorophyte, Derbesia sp. This green algal sample was collected from America Samoa, and pagoamide A was isolated using guidance by MS/MS-based molecular networking. Cultures were grown in a light- and temperature-controlled environment and harvested after several months of growth. The planar structure of pagoamide A (1) was characterized by detailed 1D and 2D NMR experiments along with MS and UV analysis. The absolute configurations of its amino acid residues were determined by advanced Marfey's analysis following chemical hydrolysis and hydrazinolysis reactions. Two of the residues in pagoamide A (1), phenylalanine and serine, each occurred twice in the molecule, once in the d- and once in the l-configuration. The biosynthetic origin of pagoamide A (1) was considered in light of other natural products investigations with coenocytic green algae.

Caldoramide, a Modified Pentapeptide from the Marine Cyanobacterium Caldora penicillata

The isolation, structure determination, and biological activities of a new linear pentapeptide, caldoramide (5), from the marine cyanobacterium Caldora penicillata from Florida are described. Caldoramide (5) has structural similarities to belamide A (4), dolastatin 10 (1), and dolastatin 15 (2). We profiled caldoramide against parental HCT116 colorectal cancer cells and isogenic cells lacking oncogenic KRAS or hypoxia-inducible factors 1α (HIF-1α) and 2α (HIF-2α). Caldoramide (5) showed differential cytotoxicity for cells containing both oncogenic KRAS and HIF over the corresponding knockout cells. LCMS dereplication indicated the presence of caldoramide (5) in a subset of C. penicillata samples.

Grassystatins A-C from marine cyanobacteria, potent cathepsin E inhibitors that reduce antigen presentation

In our efforts to exploremarine cyanobacteria as a source of novel bioactive compounds, we discovered a statine unit-containing linear decadepsipeptide, grassystatin A (1), which we screened against a diverse set of 59 proteases. We describe the structure