(3R,5S,E)-7-(2-cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl)-3,5-dihydroxyhept-6-enoic acid (R)-NEA salt

Base Information

Chemical Name:(3R,5S,E)-7-(2-cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl)-3,5-dihydroxyhept-6-enoic acid (R)-NEA salt
CAS No.:1213706-08-1
Molecular Formula:C₁₂H₁₃N*C₂₅H₂₄FNO₄
Molecular Weight:592.71
Hs Code.:

Synonyms:(3R,5S,E)-7-(2-cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl)-3,5-dihydroxyhept-6-enoic acid (R)-NEA salt

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Chemical Property of (3R,5S,E)-7-(2-cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl)-3,5-dihydroxyhept-6-enoic acid (R)-NEA salt

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Technology Process of (3R,5S,E)-7-(2-cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl)-3,5-dihydroxyhept-6-enoic acid (R)-NEA salt

There total 6 articles about (3R,5S,E)-7-(2-cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl)-3,5-dihydroxyhept-6-enoic acid (R)-NEA salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

: 3886-70-2
(R)-1-(1-Naphthyl)ethylamine

: 147526-32-7,147511-69-1,688735-41-3,769908-13-6,121659-03-8
pitavastatin

: 1213706-08-1
(3R,5S,E)-7-(2-cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl)-3,5-dihydroxyhept-6-enoic acid (R)-NEA salt

Guidance literature:: In hexane; acetone; at 20 ℃; for 16h;

Reference yield:

: 1343494-43-8
(R)-1-benzyl 7-methyl 5-(tert-butyldimethylsilyloxy)-3-oxoheptanedioate

: 1213706-08-1
(3R,5S,E)-7-(2-cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl)-3,5-dihydroxyhept-6-enoic acid (R)-NEA salt

Guidance literature:: Multi-step reaction with 6 steps

1.1: hydrogen / palladium 10% on activated carbon / ethyl acetate / 2 h / 20 °C / Inert atmosphere

2.1: piperidine / N,N-dimethyl-formamide / 10.25 h / 20 - 40 °C / Inert atmosphere

3.1: hydrogenchloride / water; methanol / 0 - 20 °C

4.1: sodium tetrahydroborate; diethyl methoxy borane / tetrahydrofuran; methanol / 0.5 h / -78 °C

4.2: 1 h / 50 °C

5.1: sodium hydroxide; water / methanol / 2 h / 20 °C

6.1: hexane; acetone / 16 h / 20 °C

With piperidine; hydrogenchloride; sodium tetrahydroborate; diethyl methoxy borane; water; hydrogen; sodium hydroxide; palladium 10% on activated carbon; In tetrahydrofuran; methanol; hexane; water; ethyl acetate; N,N-dimethyl-formamide; acetone;

Reference yield:

: 1343494-44-9
(R)-5-(tert-butyldimethylsilyloxy)-7-methoxy-3,7-dioxoheptanoic acid

: 1213706-08-1
(3R,5S,E)-7-(2-cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl)-3,5-dihydroxyhept-6-enoic acid (R)-NEA salt

Guidance literature:: Multi-step reaction with 5 steps

1.1: piperidine / N,N-dimethyl-formamide / 10.25 h / 20 - 40 °C / Inert atmosphere

2.1: hydrogenchloride / water; methanol / 0 - 20 °C

3.1: sodium tetrahydroborate; diethyl methoxy borane / tetrahydrofuran; methanol / 0.5 h / -78 °C

3.2: 1 h / 50 °C

4.1: sodium hydroxide; water / methanol / 2 h / 20 °C

5.1: hexane; acetone / 16 h / 20 °C

With piperidine; hydrogenchloride; sodium tetrahydroborate; diethyl methoxy borane; water; sodium hydroxide; In tetrahydrofuran; methanol; hexane; water; N,N-dimethyl-formamide; acetone;