(3R,5S,E)-7-(2-cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl)-3,5-dihydroxyhept-6-enoic acid (R)-NEA salt

Base Information

• Chemical Name: (3R,5S,E)-7-(2-cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl)-3,5-dihydroxyhept-6-enoic acid (R)-NEA salt
• CAS No.: 1213706-08-1
• Molecular Formula: C₁₂H₁₃N*C₂₅H₂₄FNO₄
• Molecular Weight: 592.71
• Mol file: 1213706-08-1.mol

Synonyms:(3R,5S,E)-7-(2-cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl)-3,5-dihydroxyhept-6-enoic acid (R)-NEA salt

Chemical Property of (3R,5S,E)-7-(2-cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl)-3,5-dihydroxyhept-6-enoic acid (R)-NEA salt

Chemical Property:

Purity/Quality:

Safty Information:

• Pictogram(s):  
• Hazard Codes: 

MSDS Files:

Useful:

Technology Process of (3R,5S,E)-7-(2-cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl)-3,5-dihydroxyhept-6-enoic acid (R)-NEA salt

There total 6 articles about (3R,5S,E)-7-(2-cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl)-3,5-dihydroxyhept-6-enoic acid (R)-NEA salt which guide to synthetic route it. The literature collected by LookChem mainly comes from the sharing of users and the free literature resources found by Internet computing technology. We keep the original model of the professional version of literature to make it easier and faster for users to retrieve and use. At the same time, we analyze and calculate the most feasible synthesis route with the highest yield for your reference as below:

synthetic route:

Reference yield:

(R)-1-(1-Naphthyl)ethylamine (3886-70-2) + pitavastatin (147526-32-7,147511-69-1,688735-41-3,769908-13-6,121659-03-8) → (3R,5S,E)-7-(2-cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl)-3,5-dihydroxyhept-6-enoic acid (R)-NEA salt (1213706-08-1)

Guidance literature:

In hexane; acetone; at 20 ℃; for 16h;

Reference yield:

(R)-1-benzyl 7-methyl 5-(tert-butyldimethylsilyloxy)-3-oxoheptanedioate (1343494-43-8) → (3R,5S,E)-7-(2-cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl)-3,5-dihydroxyhept-6-enoic acid (R)-NEA salt (1213706-08-1)

Guidance literature:

Multi-step reaction with 6 steps

1.1: hydrogen / palladium 10% on activated carbon / ethyl acetate / 2 h / 20 °C / Inert atmosphere

2.1: piperidine / N,N-dimethyl-formamide / 10.25 h / 20 - 40 °C / Inert atmosphere

3.1: hydrogenchloride / water; methanol / 0 - 20 °C

4.1: sodium tetrahydroborate; diethyl methoxy borane / tetrahydrofuran; methanol / 0.5 h / -78 °C

4.2: 1 h / 50 °C

5.1: sodium hydroxide; water / methanol / 2 h / 20 °C

6.1: hexane; acetone / 16 h / 20 °C

With piperidine; hydrogenchloride; sodium tetrahydroborate; diethyl methoxy borane; water; hydrogen; sodium hydroxide; palladium 10% on activated carbon; In tetrahydrofuran; methanol; hexane; water; ethyl acetate; N,N-dimethyl-formamide; acetone;

Reference yield:

(R)-5-(tert-butyldimethylsilyloxy)-7-methoxy-3,7-dioxoheptanoic acid (1343494-44-9) → (3R,5S,E)-7-(2-cyclopropyl-4-(4-fluorophenyl)quinolin-3-yl)-3,5-dihydroxyhept-6-enoic acid (R)-NEA salt (1213706-08-1)

Guidance literature:

Multi-step reaction with 5 steps

1.1: piperidine / N,N-dimethyl-formamide / 10.25 h / 20 - 40 °C / Inert atmosphere

2.1: hydrogenchloride / water; methanol / 0 - 20 °C

3.1: sodium tetrahydroborate; diethyl methoxy borane / tetrahydrofuran; methanol / 0.5 h / -78 °C

3.2: 1 h / 50 °C

4.1: sodium hydroxide; water / methanol / 2 h / 20 °C

5.1: hexane; acetone / 16 h / 20 °C

With piperidine; hydrogenchloride; sodium tetrahydroborate; diethyl methoxy borane; water; sodium hydroxide; In tetrahydrofuran; methanol; hexane; water; N,N-dimethyl-formamide; acetone;

upstream raw materials:

(R)-1-(1-Naphthyl)ethylamine

pitavastatin

(R)-1-benzyl 7-methyl 5-(tert-butyldimethylsilyloxy)-3-oxoheptanedioate

(R)-5-(tert-butyldimethylsilyloxy)-7-methoxy-3,7-dioxoheptanoic acid

Downstream raw materials:

pitavastatin calcium salt