Technology Process of (R)-1-benzyl 7-methyl 5-(tert-butyldimethylsilyloxy)-3-oxoheptanedioate
There total 1 articles about (R)-1-benzyl 7-methyl 5-(tert-butyldimethylsilyloxy)-3-oxoheptanedioate which
guide to synthetic route it.
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synthetic route:
- Guidance literature:
-
malonic acid monobenzyl ester;
With
isopropylmagnesium chloride;
In
tetrahydrofuran;
at 0 - 50 ℃;
Inert atmosphere;
(R)-3-((tert-butyldimethylsilyl)oxy)-5-(1H-imidazol-1-yl)-5-oxopentanoate methyl ester;
In
tetrahydrofuran;
at 20 ℃;
for 12h;
With
hydrogenchloride;
In
tetrahydrofuran; water;
- Guidance literature:
-
Multi-step reaction with 5 steps
1.1: hydrogen / palladium 10% on activated carbon / ethyl acetate / 2 h / 20 °C / Inert atmosphere
2.1: piperidine / N,N-dimethyl-formamide / 10.25 h / 20 - 40 °C / Inert atmosphere
3.1: hydrogenchloride / water; methanol / 0 - 20 °C
4.1: sodium tetrahydroborate; diethyl methoxy borane / tetrahydrofuran; methanol / 0.5 h / -78 °C
4.2: 1 h / 50 °C
5.1: sodium hydroxide; water / methanol / 2 h / 20 °C
With
piperidine; hydrogenchloride; sodium tetrahydroborate; diethyl methoxy borane; water; hydrogen; sodium hydroxide;
palladium 10% on activated carbon;
In
tetrahydrofuran; methanol; water; ethyl acetate; N,N-dimethyl-formamide;
- Guidance literature:
-
Multi-step reaction with 7 steps
1.1: hydrogen / palladium 10% on activated carbon / ethyl acetate / 2 h / 20 °C / Inert atmosphere
2.1: piperidine / N,N-dimethyl-formamide / 10.25 h / 20 - 40 °C / Inert atmosphere
3.1: hydrogenchloride / water; methanol / 0 - 20 °C
4.1: sodium tetrahydroborate; diethyl methoxy borane / tetrahydrofuran; methanol / 0.5 h / -78 °C
4.2: 1 h / 50 °C
5.1: sodium hydroxide; water / methanol / 2 h / 20 °C
6.1: hexane; acetone / 16 h / 20 °C
7.1: hydrogenchloride / ethyl acetate; water / pH 4.1
7.2: pH 10
7.3: 16 h / 20 °C
With
piperidine; hydrogenchloride; sodium tetrahydroborate; diethyl methoxy borane; water; hydrogen; sodium hydroxide;
palladium 10% on activated carbon;
In
tetrahydrofuran; methanol; hexane; water; ethyl acetate; N,N-dimethyl-formamide; acetone;
